
a16z partners and builders on what AI is changing
The gist
The a16z Show comes from Andreessen Horowitz, and in several episodes the firm's own partners run the interviews. Its guests range from Waymo's Dmitri Dolgov on scaling driverless rides to a former YC founder who homeschools her children with help from a team of AI agents.
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About The a16z Show
The a16z Show is Andreessen Horowitz's conversation series, and AI runs through talks as different as driverless cars, coding tools and homeschooling. Sometimes the firm's own people sit on both sides of the table. General partner Alex Rampell questions co-founder Ben Horowitz at the Fintech Connect conference in Deer Valley. Another a16z general partner joins a talk with signüll, an online commentator who writes under a Shakespeare avatar. Catherine Boyle and Sarah Wang interview a former YC founder about running a busy household with AI agents. Outside guests widen the frame. Waymo's Dmitri Dolgov describes the company's work as building a driver: a model that understands the physical world and the social side of the road. He says Waymo has moved past core research into accelerated global scaling, and he is clear that the engineering is not finished. The talk gets specific, down to debris falling off freeways and snowy conditions. Replit's CEO tells of growing up in Jordan, unable to afford a computer, and of refusing a billion-dollar offer for his company. His reason: he thinks he can build a trillion-dollar one. Many episodes begin with a short narrated essay before any guest speaks. One recalls Fred Brooks' mythical man-month and says the rule no longer holds now that GPUs and data can compress years of development into weeks. Another goes back to the 1950s, when labor-saving appliances made laundry daily and meals more elaborate without cutting the hours. That framing gives each conversation a thesis to test. The questions lean toward an investor's concerns. If customer lock-in, proprietary data and switching costs are all eroding at once, what makes a company worth building, funding or keeping? Would a builder skip a movie or a bottle of wine to spend the money on tokens? Some of the answers are surprisingly domestic. The homeschooling founder's agents now spin up other agents without her touching the machine, and she leaves her children bored on purpose because she believes boredom is a skill worth teaching. The signüll conversation turns to how models develop personality and why agents still feel primitive to many people. The cold open of the Ben Horowitz episode runs through shortages of rare earth minerals, electricity, manufacturing capacity and memory. For a first listen, 'From Models to Mobility: Building Waymo with Dmitri Dolgov' shows the show at its most concrete, and 'Building Agents at Home: Parenting, Work, and Benevolent Neglect' shows how far past the office its curiosity goes.
Made for: Suits a listener who follows startups and venture capital and wants AI grounded in concrete cases, from driverless rides to household agents, along with frank questions about moats, costs and funding.
What sets it apart: It comes from a venture firm whose partners sometimes do the interviewing, so the AI conversation keeps coming back to what makes a company worth funding. Many episodes also open with a short narrated essay that tests an old rule, like the mythical man-month, before the guest speaks.
In their own words
The a16z Show discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This show is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
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Episodes
- 1
Network Effects, AI Costs, and the Future of Consumer Investing with Anish Acharya on The Kevin Rose Show
Hidden gemKevin Rose and Anish Acharya discuss how AI lets individuals build software such as CRMs and Slack competitors while weakening traditional engineering-based moats.
Apr 19, 2026·59m·4 clips - 2
From Models to Mobility: Building Waymo with Dmitri Dolgov
Waymo co-CEO Dmitry Dolgov tells John Collison how Waymo combines cameras, LIDAR, radar, onboard AI, simulation, and critic models to operate autonomous vehicles.
Apr 17, 2026·1h 4m·5 clips - 3
Technology, Culture, and the Next AI Interface with signüll
A discussion on the challenges of AI personality development and making AI more accessible, featuring Signal and an A16Z general partner.
Apr 16, 2026·34m - 4
Replit's CEO on Vibe Coding, Wealth Building, and What Most People Get Wrong About AI
Replit's CEO Amjad Massad discusses his mission to democratize coding, his refusal to sell for $1 billion, and his vision for AI empowering everyone to build software.
Apr 15, 2026·1h 39m·2 clips - 5
Ben Horowitz on AI Infrastructure, Economics and The New Laws of Software
Ben Horowitz discusses the need to rebuild US infrastructure for AI, the end of the 'mythical man month' rule, and how GPUs and data are disrupting software development and business moats.
Apr 14, 2026·30m·2 clips - 6
Building Agents at Home: Parenting, Work, and Benevolent Neglect
Hidden gemA former YC founder homeschools four young children using 11 AI agents, embracing 'benevolent neglect' to teach boredom as a skill.
Apr 13, 2026·55m·2 clips - 7
What Running Windows at Microsoft Taught Steven Sinofsky About Apple
Steven Sinofsky discusses the cultural differences between Apple and Microsoft, highlighting Apple's artist culture versus Microsoft's technologist culture, and the role of taste in their success.
Apr 10, 2026·31m - 8
Who Controls AI Acceleration? Vitalik Buterin and Guillaume Verdon Debate
Apr 9, 2026·1h 39m - 9
The Agent Era: Building Software Beyond Chat with Box CEO Aaron Levie
Apr 8, 2026·1h - 10
Balaji on Why AI Raises the Cost of Verification
Apr 7, 2026·1h 7m - 11
Peter Yang on Small Teams, Coding Agents, and Why Human Ambition Has No Ceiling
Apr 6, 2026·29m - 12
Marc Andreessen on AI Winters and Agent Breakthroughs
Apr 3, 2026·1h 17m - 13
Alex Blania on Proof of Human and Building World's Identity Network
Apr 2, 2026·42m - 14
What Happens When a Public Company Goes All In on AI
Apr 1, 2026·28m - 15
How Radiant and Heron Are Rethinking Power Generation and Delivery
Mar 31, 2026·49m - 16
Marc Andreessen on Evaluating Founders and AI's Consumer Surplus
Mar 30, 2026·1h 8m - 17
The SpaceX and Tesla Playbook for Hard Tech Startups
Mar 27, 2026·51m - 18
Security, Resilience, and the Future of Mobile Infrastructure
Mar 26, 2026·41m - 19
Submarines and the Future of Defense Manufacturing
Mar 25, 2026·24m - 20
The Missing Power Layer of Modern Warfare
Mar 24, 2026·51m - 21
Why Every Satellite Needs Earth | Northwood CEO on a16z
Mar 23, 2026·41m - 22
Inside Palantir: Building Software That Matters with Shyam Sankar
Mar 20, 2026·55m - 23
AI Just Gave You Superpowers — Now What?
Mar 19, 2026·1h 6m - 24
AI, Supply Chains, and the Future of Economic Power
Mar 18, 2026·37m - 25
What's Missing Between LLMs and AGI - Vishal Misra & Martin Casado
Mar 17, 2026·48m - 26
AI Startups vs. Big Chatbots — With Olivia Moore
Olivia Moore from A16Z discusses how AI startups can compete with large AI chatbots like ChatGPT, Claude, and Gemini.
Mar 16, 2026·57m - 27
Marc Andreessen on the Mindset of Great Founders — with David Senra
Mar 15, 2026·1h 49m - 28
Emil Michael: Iran, Anthropic and the Future of AI at the Pentagon
Mar 13, 2026·28m - 29
Palantir CEO Alex Karp on the Zero-Sum AI Race
Mar 12, 2026·33m - 30
What It Takes to Clear a Million Crimes a Year with Flock Safety's CEO
Flock Safety CEO Garrett Langley discusses how his company's technology, from license plate readers to drones and AI, helps police clear over a million crimes annually by shifting from reactive to real-time policing.
Mar 11, 2026·1h 47m - 31
The Top 100 Gen AI Consumer Apps
Mar 10, 2026·41m - 32
Andrew Huberman: Peptides, Sleep Tech, and the End of Obesity
Mar 9, 2026·52m - 33
Atlassian CEO on the SaaS Apocalypse, AI Agents & What Comes Next
Mar 6, 2026·55m - 34
Ben Thompson: Anthropic, the Pentagon, and the Limits of Private Power
Mar 5, 2026·37m - 35
Ambience CEO Nikhil Buduma on AI in Clinical Workflows
Mar 4, 2026·49m - 36
Ben Horowitz On What Makes a Great Founder
Mar 3, 2026·51m - 37
Chris Dixon: From Quant Trading to Building a16z Crypto
Mar 2, 2026·1h - 38
a16z's New Media Playbook
Feb 27, 2026·48m - 39
When Giants Don’t Go Public: Inside the $5 Trillion Private Tech Market
Feb 26, 2026·47m - 40
Ben Horowitz: RSI, Crypto as AI Money, & Classified Physics
Feb 23, 2026·1h 48m - 41
Patrick Collison on Stripe’s Early Choices, Smalltalk, and What Comes After Coding
Feb 20, 2026·53m - 42
Capital, Compute, and the Fight for AI Dominance
Feb 19, 2026·58m - 43
From Copilots to Agents: Rebuilding the Company Around AI
Feb 18, 2026·1h - 44
WSJ x a16z: The Next 25 Years of Defense Innovation
Feb 17, 2026·31m - 45
Novartis CEO Vasant Narasimhan on Transforming a 250-Year-Old Company
Feb 16, 2026·58m - 46
Balaji and Dan Wang: The Engineering State vs Lawyerly State
Balaji Srinivasan and Dan Wang debate the strengths and weaknesses of the US and China, focusing on manufacturing, industrialization, and the concept of an engineering state versus a lawyerly state.
Feb 13, 2026·1h 4m - 47
Anish Acharya: Is SaaS Dead in a World of AI?
Feb 12, 2026·1h 22m - 48
How Magic Johnson Built a Billion-Dollar Portfolio in 30 Years
Feb 11, 2026·1h 6m - 49
Marc Andreessen: Who Runs the World’s AI?
Feb 10, 2026·26m - 50
The State of Markets
Feb 9, 2026·48m