Shirtloads of Science

150 episodes listed below

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Real specialists, plain questions, and Dr Karl's running jokes.

The gist

Dr Karl questions scientists and specialists at the microphone, making them define their jargon and trading jokes as he goes. The subjects range widely, from forensic DNA contamination and the supplement trade to microplastics in the body, artificial eardrums and a fix for the James Webb telescope's focus.

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About Shirtloads of Science

Shirtloads of Science, produced by the University of Sydney, runs on a simple frame: Dr Karl welcomes a researcher or specialist to the microphone and asks them to explain their work. That frame barely changes. Episodes typically open with an acknowledgement of the Gadigal people of the Eora Nation and close on a laundry pun, with the sign-off that the show is washed, spun and aired by the university. What happens in between depends on the guest, and the guests cover a lot of ground. Hannah Gould talks about death cafes, informal meetups in cafes, funeral homes and local libraries where people get to ask the questions about dying they never had a chance to raise. Her framing is disarming: talking about death will not make anyone die, any more than talking about sex makes anyone pregnant. She admits she still grieves her first pet, a rabbit, and the conversation ends with a cheerful 'have a good death.' The forensic conversation with Linzi Wilson-Wilde and Hannah Jarman starts from Dr Karl's impatience with television crime labs and their magic 'enhance' button. From there it moves to two pairs of gloves, hoods and masks, the constant fight to keep a DNA lab free of human DNA, and a case in which 40 matches turned out to be contamination. Kate Thomas, trained as a pharmacist, is asked about the supplement industry and about how differently drug companies deal with prescribers in America. The same conversation draws a confession: Dr Karl once bought a 50-kilo drum of vitamin C after reading Linus Pauling, then sold it to friends in smaller lots. With Michaela Lucas, an immunologist, the question is how much plastic ends up in a human body. He pushes for a number, the estimate drifts toward a gram or less, and she stresses that most research in the field consists of association studies, not randomized trials. A story about the James Webb telescope, told with Peter Tuthil, Louis Desdoigts and Max Charles, went horribly wrong, then right, and by Dr Karl's account ended in tattoos. The feed also carries repeats marked RPT, one introduced with a note that Dr Karl is on sabbatical overseas, working on a strategy that uses artificial intelligence against climate change disinformation. In that repeat, Marcus Atlas discusses chronic middle ear infection with a perforated eardrum, a condition whose complications can reach the brain and which is described as a real problem in developing parts of the world. Dr Karl's habits give the show its texture. He asks what epistemic means and what CSOM stands for. Names get spelled out letter by letter, and one guest is thanked by each of her titles in turn. The result is specialist knowledge that has been stopped, questioned and translated along the way. For a first listen, the death conversation is a warm way in, and the James Webb story has a genuine turnaround.

Made for: Suits a listener who wants current research explained by the people doing it, and who likes an interviewer that stops to ask what a word means before moving on. It fits someone curious about health claims, forensic evidence or space engineering who prefers conversation to lectures.

What sets it apart: The show relies as much on Dr Karl's own asides as on the guests' expertise: a confessed 50-kilo vitamin C purchase, mock homework on the second Lagrangian point, teasing about academic titles. Under one University of Sydney banner, the subjects move from death studies to forensics to telescope optics.

In their own words

Dr Karl's a curious optimist – a great combination for a science lover. Join him and his guests for weird facts, amazing conversation and remember, it's never too late for a happy childhood. https://drkarl.com/

As heard by us

Based on 5 episodes we listened to · September 2026

Dr Karl turns specialist interviews into candid lessons about evidence, uncertainty and the practical work behind scientific knowledge.

Shirtloads of Science lets Dr Karl follow a practical question until the science and its uncertainties come into view. His interviews move freely between death customs, the calibration of James Webb data, wellness claims, microplastics research and forensic evidence.

Read our full review in PlayNext →

Why you'd press play

Dr Karl once bought a 50-kilo drum of vitamin C; you get his questions, not his leftovers.

Press play if you want

  • to ask what a "good death" means without expecting one neat answer
  • to hear how researchers rebuilt a software pipeline to make sense of James Webb telescope data
Read the full recommendation in PlayNext →
Health and medical researchDeath, dying and griefForensic science and evidence reliabilityWellness claims and supplementsMicroplastics and healthSpace telescopes and astronomyHearing and ear medicine

Talks about

Best episodes of Shirtloads of Science

Short reviews from the PlayNext desk, based on the episodes we processed.

How To Die in the 21st Century with Dr. Hannah Gould (469)Apr 11, 2026

A calm look at how death gets defined, discussed, and brought back down to earth.

Dr. Carl opens with a joke about death not being contagious, then gives Dr. Hannah Gould space to make the case that a good death is never a fixed thing.

How Two Students Fixed the Focus of James Webb from Earth with Prof. Peter Tuthil, Dr. Louis Desdoigts & Max Charles (468)Apr 4, 2026

A practical JWST problem-solving story that tracks the shift from early data trouble to a rebuilt pipeline.

Shirtloads of Science follows a JWST problem being diagnosed after the telescope reached L2, about a million kilometres from Earth, and shows how the team came to understand that the first results did not match expectations.

Forensic Science: Fact, Fiction, and Failure with Dr Linzi Wilson-Wilde and Hannah Jarman (467)Mar 28, 2026

Forensic science gets stripped of TV gloss and rebuilt around contamination, standards, and consequence.

Shirtloads of Science takes a close look at the forensic science television usually glosses over, from the gloves, gowns, booties, hairnets, mask, and antechamber that help keep DNA work contamination-free.

The Wellness Woo Economy with Kate Thomas (466)Mar 21, 2026

A pharmacist-led, evidence-minded tour through wellness claims, vitamin talk, and the appeal of supplement promises.

Kate Thomas, a pharmacist and social media science communicator, gives this Shirtloads of Science episode its clearest thread: a steady look at how wellness claims spread, from a saffron latte sold as an anxiety cure to the wider supplement industry.

The Hidden Health Impact of Microplastics with Prof. Michaela Lucas (465)Mar 14, 2026

Microplastics are the headline; measurement is the real story.

Shirtloads of Science treats plastics and microplastics as a problem of measurement first and disease claims second. Dr Karl and Professor Michaela Lucas move from microplastics in water and the word plasticenter to the harder question of what any finding can really prove.

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    Hypersonics Part One with Dr. Graham Wild (432)

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    Health Misinformation on Social Media & Overdiagnosis with Dr Brooke Nickel (428)

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    Fluoride in Drinking Water with Dr Michael Foley (425)

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    RPT Growing Ear Drums with Professor Marcus Atlas

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    How To Die in the 21st Century with Dr. Hannah Gould (469)

    Hidden gem

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    How Two Students Fixed the Focus of James Webb from Earth with Prof. Peter Tuthil, Dr. Louis Desdoigts & Max Charles (468)

    Hidden gem

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    Forensic Science: Fact, Fiction, and Failure with Dr Linzi Wilson-Wilde and Hannah Jarman (467)

    Hidden gem

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    The Wellness Woo Economy with Kate Thomas (466)

    Hidden gem

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    The Hidden Health Impact of Microplastics with Prof. Michaela Lucas (465)

    Hidden gem

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    Mar 14, 2026·32m·3 clips
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    The Rise In Nitrous Misuse with Assoc. Prof. Angela Chiew (463)

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    Will AI Take Our Jobs? Part Three of the Great AI Safety Debrief with Dr. Petr Lebedev (462)

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    The Milky Way's Mysterious Glow with Prof. Geraint Lewis (459)

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    Food Additives: What's Safe, What's Not? with Prof. Clare Collins (451) [REPEAT]

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    Staying Safe Online Part 2 with Troy Hunt (439) [REPEAT]

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    The Human Side of Misinformation Part 2 with Assoc. Prof. Marian-Andrei Rizoiu (445) [REPEAT]

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    Gene Therapy & Rare Diseases with Assoc. Prof Leszek Lisowski (449)

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    Oct 18, 2025·31m
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    Oct 11, 2025·29m
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    The Aftermath of Cosmic Collisions with Prof. Geraint Lewis (446)

    Oct 4, 2025·27m
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    The Human Side of Misinformation Part 1 with Assoc. Prof. Marian-Andrei Rizoiu (444)

    Sep 20, 2025·31m
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    Science Under Siege with Prof. Michael Mann & Prof. Peter Hotez (443)

    Sep 13, 2025·33m
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    From DNA to Policy: Protecting Threatened Species with Prof. Carolyn Hogg (442)

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    Whales, Wildlife, and Conserving Threatened Species with Prof. Carolyn Hogg (441)

    Aug 30, 2025·27m
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    Have I been Pwned? With Troy Hunt (438)

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    A Conversation with Nobel Laureate Professor Donna Strickland (436)

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    Part 2 with Prof. Carolyn Hogg (442)

    Jul 8, 2025·25m
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    RPT Ballooning for Dark Matter with Dr Sirks

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