Radiolab is produced by WNYC Studios and hosted by Lulu Miller and Latif Nasser, with executive editor Soren Wheeler occasionally cohosting live tapings. Each episode is constructed as a single narrative arc rather than a structured interview, following a reporter through labs, archives, or communities to answer one specific question. Recurring subject areas include neuroscience and lab-grown brain organoids, evolutionary biology, wildlife and conservation, infectious disease and public health, and the history of science, with occasional episodes on technology and artificial intelligence. Guests are typically the working scientists, historians, or activists at the center of a given story — such as a neuroscientist who accidentally created the first brain organoids, or a physician studying antibiotic resistance — rather than recurring commentators, though science writer Carl Zimmer reappears across multiple episodes as a contextualizing voice. The show also produces Terrestrials, a spinoff for younger listeners covering nature topics like beaver dams and moon trees. Some episodes are turned over entirely to allied WNYC series, including one on a journalist building an AI-staffed startup and another on Appalachian coal-mining communities and music. Episodes run roughly 30 to 60 minutes and lean on field recordings, archival audio, and layered sound design rather than a simple two-person conversation. Listeners who want conclusions stated up front may find the tape-driven build slower going, while those interested in watching scientific or historical discovery unfold are better served. The show draws on a long back catalog, at times revisiting or updating stories first reported a decade or more earlier. Cross-promotion for other public radio podcasts appears in some episodes' mid-rolls.