Quirks and Quarks is a weekly interview-based science magazine produced by CBC Radio and hosted by Bob McDonald, who frames each episode and introduces roughly four to five separate guest segments per show. Guests are typically PhD students, postdocs, and professors at North American and European universities, each explaining a specific study they authored or co-authored, drawn from institutions such as the University of Reading, Imperial College London, Case Western Reserve University, and Michigan State University. Recurring subject areas include evolutionary biology and animal behavior (cricket courtship, seal vocal mimicry, raccoon and cockroach adaptability), paleontology and ancient life (fossilized dinosaur vomit, armored-fish jaw structure, early hominin bipedalism), and space and planetary science (the Artemis II mission, moon-formation theory, exoplanets, the interiors of Uranus and Neptune). Segments on human health, nutrition, and emerging technology also recur, covering topics like gut-microbiome toxicology, HIV latency, and organoid-based biocomputing. Episodes regularly mix current research news with archival material, including occasional full retrospectives that replay decades-old Quirks and Quarks segments. Short cross-promotional inserts for other CBC podcasts, such as Bookends, This Is Ottawa, and Commotion, appear within some episodes. There is no season-long narrative; each episode is a self-contained set of unrelated science stories rather than a continuing investigation. The explanations are aimed at a general audience with an interest in current research rather than specialists, using accessible, non-technical language. Listeners who want a recurring digest of new findings across many scientific disciplines, rather than a deep dive into one field, are the primary beneficiaries. Production follows a traditional public-radio segment structure without heavy narrative sound design.