Making Sense of Pregnancy: What Experts Want you To Know About Your Body

Paulette Kamenecka

87 episodes listed below

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Pregnancy science with a steady hand.

The gist

Making Sense of Pregnancy treats pregnancy as a complex biological system, not a set of tidy milestones. Its conversations move from ovaries and implantation to placentas, fetal sex, immune cells, postpartum depression, and hemorrhage prediction.

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About Making Sense of Pregnancy: What Experts Want you To Know About Your Body

Making Sense of Pregnancy approaches pregnancy as a living research frontier. It is not built around quick tips. The show works best when it follows a biological process from first principle to clinical consequence, asking how a pregnancy begins, adapts, and sometimes runs into trouble. Ovaries are treated as dynamic organs, not background anatomy. Implantation becomes a negotiation between embryo, uterine lining, hormones, growth factors, and specialized cells. The placenta is not just an afterthought after conception; it is a central actor whose development can shape preeclampsia, intrauterine growth restriction, preterm birth, and other outcomes. The show is especially attentive to early pregnancy, where major downstream risks may begin before a patient has much contact with routine care. It also makes room for the mother after birth. Episodes on postpartum depression and postpartum hemorrhage ask how risk might be predicted before crisis or symptoms arrive. The interview format is measured and explanatory. Dense answers are often restated in plainer language, then tested against a concrete model or sequence. That gives the show a useful rhythm: technical vocabulary appears, but it rarely sits unexplained. A 3-D uterine lining model is described not as a novelty, but as a tool for seeing the conversation between embryo and decidua. Blastocysts, blastoids, trophoblast cells, ovarian reserve, methylation, biomarkers, fetal sex, and uterine natural killer cells all become part of the same larger question. How much does current science actually understand about pregnancy? The show is comfortable saying that the answer is incomplete. It is also comfortable being excited by a good experiment. The result is a pregnancy science show with warmth, restraint, and real curiosity. It suits listeners who want more than reassurance and less than medical theater. Its strongest moments make complex reproductive biology feel legible without pretending it is simple.

Made for: For pregnant people, postpartum people, birth workers, clinicians, and science-minded listeners who want careful explanations of reproductive biology and maternal health research. It is especially suited to those who can handle uncertainty when it is clearly mapped.

What sets it apart: The show connects early biological mechanisms to later pregnancy and postpartum outcomes, rather than treating complications as isolated events. Its strength is patient translation of current research without sanding away the complexity.

In their own words

Have you been surprised by what we do and don't know about pregnancy and birth today? If you are pregnant, or have been in the past, this show helps you understand what's happening (or has happened) to our bodies--both the short term and long term effects of this transformation. We explore the boundaries of our scientific grasp on the wildly complex processes of pregnancy and birth. After my complicated pregnancies, I went looking for answers and have interviewed hundreds of experts about women's health in this transition. Every Tuesday you'll hear:Scientists at the cutting edge who are trying to un...

As heard by us

Based on 5 episodes we listened to · September 2026

Detailed reproductive research becomes legible here without losing the uncertainty around implantation, pregnancy complications and postpartum mental health.

Making Sense of Pregnancy follows the biology that begins long before birth complications become visible. The host moves between solo explanation and researcher interviews, tracing ovarian follicle development, implantation, placental construction and the immune activity of…

Read our full review in PlayNext →

Why you'd press play

Implantation gets the full laboratory close-up when you want pregnancy biology beyond the pamphlet.

Press play if you want

  • the cellular negotiations behind implantation explained without pretending the science is settled
  • a clear route from sleeping ovarian follicles to the construction of a placenta
Read the full recommendation in PlayNext →
implantation biologyplacental developmentovarian reserve and agingfetal sex differencespregnancy complicationspostpartum depression biomarkerspostpartum hemorrhage predictionimmune cells in early pregnancy

Talks about

Best episodes of Making Sense of Pregnancy: What Experts Want you To Know About Your Body

Short reviews from the PlayNext desk, based on the episodes we processed.

Ovaries: the living Vault of your FertilityApr 15, 2026

A clear, patient review of the ovary as an active keeper of eggs, from fetal development to ovulation.

Ovaries carry the episode's main weight, as it follows how eggs form before birth, settle into a long pause, and may later be selected during a cycle for ovulation.

Opening the black box of implantation with a model uterine lining: Conversation with Dr. Irene Zorzan, Part IIApr 8, 2026

A clear look at implantation, embryo models, and where the blastoid still differs from a human embryo.

The episode stays close to the mechanics of implantation, showing how a carefully built uterine lining behaves when blastoids, embryo models, and five day old embryos meet it.

Building a 3-D model of a uterine lining to better understand implantation: Conversation with Dr. Irene Zorzan, Part IApr 1, 2026

A careful look at implantation as an embryo-uterus exchange.

The episode treats implantation as a precise exchange between embryo and uterine lining, and the first-of-its-kind 3D model makes the early biology easier to grasp.

A Blood Test to predict the risk of Postpartum Depression: Conversation with Dr. Jennifer Payne, rebroadcastMar 11, 2026

A careful look at a blood test that could reshape postpartum depression screening.

Postpartum depression is the episode's center of gravity, and the strongest thread is its focus on catching the condition before a parent can even put it into words.

uNK Cells and the Placenta: The Immune System’s Role in Healthy Early Pregnancy, Conversation with Dr. Ashley Moffett, Part IFeb 18, 2026

A careful look at early pregnancy biology, with immune cells and placental development at the center.

The episode treats the first weeks of pregnancy as a tightly coordinated stretch, where implantation, placenta formation, and immune activity all belong to the normal process.

Podcasts like Making Sense of Pregnancy: What Experts Want you To Know About Your Body

Episodes

  1. 1

    Pregnancy’s Hidden Frontier: The Most Detailed Atlas of the Maternal-Fetal Interface, Conversation with Dr. Susan Fisher, PhD, part I

    Sep 30, 2026·29m
  2. 2

    Can your Menstrual Cycle affect your chances of Miscarriage?: Conversation with Dr. Jans Brosens, re-edited and rereleased

    Sep 23, 2026·46m
  3. 3

    Inside Human Embryo Implantation: Watching for the first time, Conversation with Dr. Amelie Godeau, Part II

    Sep 16, 2026·24m
  4. 4

    How a Human Embryo Implants-- New Insights From a 3D Model: Conversation with Dr. Amelie Godeau, Part I

    Sep 9, 2026·28m
  5. 5

    Your Menstrual Cycle is a Vital Sign: Conversation with Dr. Mahalingaiah, Part II

    Sep 2, 2026·26m
  6. 6

    What can the Menstrual Cycle Tell us about our health: Conversation with Dr. Shruthi Mahalingaiah

    Aug 26, 2026·28m
  7. 7

    What Wearables can tell us about Pregnancy & Pregnancy Loss: Conversation with Dr. Benjamin Smarr (encore)

    Aug 19, 2026·41m
  8. 8

    Sleep and Your Menstrual Cycle: Why Your Period May Become Less Predictable, Conversation with Dr. Sarah Johnson, Part II

    Aug 12, 2026·24m
  9. 9

    Using wearable technology to understand the menstrual cycle: Conversation with Dr. Sarah Johnson, Part I

    Aug 5, 2026·28m
  10. 10

    How does labor start? How do we measure labor stages? A walk through the research

    Jul 29, 2026·25m
  11. 11

    What triggers Spontaneous Labor? A research based theory: conversation with Dr. Todd Rosen (Encore)

    Jul 22, 2026·28m
  12. 12

    Looking for Patterns in your Menstrual Cycle as Keys to Overall Health: Conversation with Dr. Gombert-Labedens, Part II

    Jul 15, 2026·28m
  13. 13

    What Can we learn about overall health by examining features of the menstrual cycle?: Conversation with Dr. Gombert-Labedens, Part I

    Jul 8, 2026·25m
  14. 14

    What can an organoid teach us about the human menstrual cycle: Conversation with Dr. Margherita Turco, Part II

    Jul 1, 2026·26m
  15. 15

    Inside the Black Box of your Menstrual Cycle: Conversation with Dr. Margherita Turco, Part I

    Jun 24, 2026·27m
  16. 16

    Understanding Your Menstrual Cycle: Why It Matters, How It Works, and Why You Should Care

    Jun 17, 2026·28m
  17. 17

    Timing of Labor Induction affects C section rate: Conversation with Dr. Cortese and Dr. Hoffmann, Part II

    Jun 3, 2026·28m
  18. 18

    How the Timing of Labor Induction affects the Length of Labor: Conversation with Dr. Cortese & Dr. Hoffmann, Part I

    May 27, 2026·34m
  19. 19

    Understanding Miscarriage and Stillbirth: Conversation with Dr. Harvey Kliman, Part II

    May 20, 2026·32m
  20. 20

    Why your Miscarriage Wasn't Your Fault: Conversation with Dr. Harvey Kliman, Part 1

    May 13, 2026·39m
  21. 21

    Eavesdropping on the first trimester: using new technology to better understand early maternal-placental crosstalk, Conversation with Dr. Shirley Greenbaum

    May 6, 2026·38m
  22. 22

    IVF & Egg Banking; Emerging Tech Trends in Assisted Reproductive Technology (ART)

    Apr 29, 2026·31m
  23. 23

    Ovaries: the living Vault of your Fertility

    Hidden gem

    Making Sense of Pregnancy examines how ovarian follicles form, remain dormant for decades, and compete for ovulation, including an estimated 300-day development path.

    Apr 15, 2026·30m·2 clips
  24. 24

    Opening the black box of implantation with a model uterine lining: Conversation with Dr. Irene Zorzan, Part II

    Hidden gem

    This episode stays on implantation.

    Apr 8, 2026·24m·2 clips
  25. 25

    Building a 3-D model of a uterine lining to better understand implantation: Conversation with Dr. Irene Zorzan, Part I

    Hidden gem

    The episode opens with a bold experimental model for studying implantation.

    Apr 1, 2026·29m·2 clips
  26. 26

    How Fetal Sex influences Pregnancy Complications: Conversation with Dr. Vicki Clifton, Part II

    This episode explores how fetal sex influences pregnancy complications like gestational diabetes, discussing research on fetal and placental responses and potential sex-specific treatments.

    Mar 25, 2026·26m
  27. 27

    How the Sex of the Placenta Affects Pregnancy: Conversation with Dr. Vicki Clifton, Part I

    This episode explores how the sex of the placenta influences pregnancy outcomes and fetal development through an interview with researcher Dr.

    Mar 18, 2026·31m
  28. 28

    A Blood Test to predict the risk of Postpartum Depression: Conversation with Dr. Jennifer Payne, rebroadcast

    Hidden gem

    Postpartum depression is presented here as the most common complication of pregnancy, difficult to diagnose, and worth catching early.

    Mar 11, 2026·27m·2 clips
  29. 29

    Renovating the Uterus in Early Pregnancy: the collab between immune cells and fetal cells, Conversation with Dr. Ashley Moffett, Part 2

    Feb 25, 2026·30m
  30. 30

    uNK Cells and the Placenta: The Immune System’s Role in Healthy Early Pregnancy, Conversation with Dr. Ashley Moffett, Part I

    Hidden gem

    Early pregnancy is not quiet.

    Feb 18, 2026·30m·2 clips
  31. 31

    Why the Menstrual Cycle is so important for Fertility and Pregnancy

    Feb 11, 2026·26m
  32. 32

    Rebroadcast: Birth Trauma or Postpartum Depression? Understanding the Difference Matters, Conversation with Dr. Sharon Dekel

    Feb 4, 2026·40m
  33. 33

    Targeting the Placenta: Gene Therapy as a new treatment for fetal growth restriction: Conversation with Dr. Helen Jones, Part 2

    Jan 28, 2026·30m
  34. 34

    Can Gene Therapy fix the placenta? New hope for fetal growth restriction: Conversation with Dr. Helen Jones, Part I

    Jan 21, 2026·23m
  35. 35

    The next generation of prenatal care: how computational biology is changing obstetrics: Conversation with Dr. Liat Shenhav and Dr. Matthew Hoffman

    Jan 14, 2026·36m
  36. 36

    The Science reshaping how we manage pregnancy: Year End recap, Part II

    Jan 7, 2026·22m
  37. 37

    The Science Reshaping How we understand the first trimester: Year End recap, Part I

    Dec 31, 2025·26m
  38. 38

    REBROADCAST: Making Birth Safer, a Conversation with Dr. Elliot Main

    Dec 24, 2025·34m
  39. 39

    Early Pregnancy Is a Dialogue: How Cell Signaling Shows Mothers and Embryos Collaborate: Conversation with Dr. D Stadtmauer, Part II

    Dec 17, 2025·24m
  40. 40

    A placental origin story: what evolutionary biology can tell us, Conversation with Dr. Stadtmauer, part 1

    Dec 10, 2025·26m
  41. 41

    Who is feeding the embryo while the placenta is under construction?

    Dec 3, 2025·22m
  42. 42

    The Behind the Scenes work of your Immune system in preparing the Uterine lining for pregnancy: Conversation with Dr. Tamara Tilburgs, Part II

    Nov 26, 2025·28m
  43. 43

    When's the best time to intervene in the health of a pregnancy? Before it starts: Conversation with Dr. Tamara Tilburgs, Part I

    Nov 19, 2025·29m
  44. 44

    How we might manage early immune cell trouble in the placenta: Conversation with Dr. Nadkarni, part II

    Nov 12, 2025·25m
  45. 45

    How our most common immune cell can influence the most common birth defect: Conversation with Dr. Suchita Nadkarni, Part 1

    Nov 5, 2025·26m
  46. 46

    Is your Immune System shut off during pregnancy? (spoiler: NO)

    Oct 29, 2025·26m
  47. 47

    Your Uterine Lining determines if and how a pregnancy progesses: Conversation with Dr. Jan Brosens, Part II

    Oct 16, 2025·26m
  48. 48

    Understanding Miscarriage through Evolutionary Biology: Conversation with Dr. Jan Brosens, Part I

    Oct 8, 2025·34m
  49. 49

    Tracking Placental Inflammation in a Pregnancy While its happening: Dr. Yong Wang, Part II

    Oct 1, 2025·26m
  50. 50

    Measuring Inflammation in the Placenta in real time: Conversation with Dr. Yong Wang, Part I

    Sep 24, 2025·21m
  51. 51

    The Science of Periods: What's really going on in your Uterus

    Sep 10, 2025·20m
  52. 52

    What is the role of the Corpus Luteum in reproductive health and fertility: Conversation with Dr. Kirk Conrad

    Sep 3, 2025·45m
  53. 53

    The backstory of the Unsung Hero of Early Pregnancy: the Corpus Luteum

    Aug 27, 2025·17m
  54. 54

    Why Postpartum is not the "opposite" of pregnancy: Conversation with Dr. Uri Alon

    Aug 20, 2025·34m
  55. 55

    Can we predict miscarriage with an activity tracker? Conversation with Professor Benjamin Smarr, Part II

    Aug 6, 2025·29m
  56. 56

    Can an activity tracker tell you if you are pregnant? Conversation with Professor Benjamin Smarr, Part I

    Jul 30, 2025·25m
  57. 57

    Many long held ideas about Placental Development are wrong: a conversation with Dr. Graham Burton, PhD

    Jul 9, 2025·34m
  58. 58

    What triggers labor?: Conversation with Dr. Polina Lishko, Part 2

    Jun 25, 2025·24m
  59. 59

    Turning labor on and off: the identification of a trigger: Conversation with Dr. Polina Lishko, PhD, part I

    Jun 18, 2025·24m
  60. 60

    How the Uterine Environment Shapes the Baby's Long term Health

    Jun 11, 2025·24m
  61. 61

    Can we predict Postpartum Depression from inside the Third Trimester: Conversation with Dr. Jennifer Payne

    Jun 4, 2025·27m
  62. 62

    How to Make a Placenta: A User's Guide

    May 28, 2025·23m
  63. 63

    What would it look like to predict Postpartum Hemorrhage? A Conversation with Christine Rohan & Dr. James Weimer

    The host interviews the CEO and a founder of a company developing a device to predict postpartum hemorrhage, using insights from sports medicine.

    May 21, 2025·34m
  64. 64

    A 3-D model of a placenta (on-a-chip): Conversation with Dr. Colin Murdoch

    May 14, 2025·29m
  65. 65

    Looking into the back of your eye for insights about Pregnancy: Conversation with Dr. Li, Part II

    May 7, 2025·25m
  66. 66

    The Use of Retinal Scans to predict health conditions in pregnancy & fertility: A conversation with Dr. Li, Part I

    Apr 30, 2025·24m
  67. 67

    The Link Between shifts in your Immune System in Pregnancy & PPD: Conversation with Dr. Lauren Osborne, MD

    Apr 23, 2025·33m
  68. 68

    The Decades Long Process of Making a Viable Egg Cell

    Apr 16, 2025·20m
  69. 69

    Using the Placental Clock to Predict Preterm Birth: Conversation with Dr. Christina Herrera

    This episode features a conversation with Dr.

    Apr 9, 2025·29m
  70. 70

    Your Placenta's Origin Story

    Apr 2, 2025·28m
  71. 71

    Predicting Perinatal Depression: The Future of Maternal Mental Health, a conversation with Dr. Sheila Shanmugan

    Mar 19, 2025·31m
  72. 72

    Embryo & Endometrium Hacks to Make Implantation Happen: Amazing things your Pregnant Body Can Do

    Mar 12, 2025·22m
  73. 73

    The Connection Between the Womb and Lifelong Health: Conversation with Dr. Alison Paquette

    Mar 5, 2025·31m
  74. 74

    How your Placenta and Baby "Talk" to Decide when Labor Starts: Conversation with Dr. Todd Rosen

    Feb 26, 2025·27m
  75. 75

    Unlocking the Secrets of the Placenta with AI: Conversation with Dr. Jeffrey Goldstein

    Feb 19, 2025·29m
  76. 76

    Understanding How Uterine Contractions Work: A Key to preterm labor, period cramps and endometriosis? Conversation with Dr. Wang

    Feb 12, 2025·35m
  77. 77

    How the Endometrium's Interview Process Affects your Fertility: Conversation with Dr. Nick Macklon

    Feb 5, 2025·37m
  78. 78

    The Hidden Conversation Between the Immune System and Pregnancy: What It Means for Birth: Dr. Nardhy Gomez-Lopez

    Jan 29, 2025·32m
  79. 79

    The Surprising Role of Aspirin in Fighting Preterm Birth Risks: Conversation with Dr. Matthew Hoffman

    Jan 22, 2025·28m
  80. 80

    Does Modern Medicine Underestimate the Power of the Placenta? Conversation with Dr. Mana Parast, Part II

    Jan 15, 2025·24m
  81. 81

    What we are Missing in Pregnancy Care when we Don't Examine the Placenta, Part I: Dr. Mana Parast

    Jan 8, 2025·27m
  82. 82

    How Early Pregnancy Insights Could Transform Prenatal Care: Dr. Carl Weiner

    Jan 1, 2025·39m
  83. 83

    How New Research on Uterine Contractions Could Revolutionize Labor Monitoring: Dr. Roger Young

    Dec 25, 2024·26m
  84. 84

    Why ‘It’s Just Postpartum Depression’ Misses the Mark for So Many Mothers: Dr. Sharon Dekel, PhD

    Dec 18, 2024·42m
  85. 85

    It's not "Mommy Brain"-How Hormones during Pregnancy Prepare the Brain for Parenting: A Conversation with Dr. Laura Pritschet

    Dec 11, 2024·32m
  86. 86

    How Maternal Health Data Is Saving Lives: A conversation with Dr. Elliot Main

    Dec 4, 2024·34m
  87. 87

    Welcome to Making Sense of Pregnancy

    Nov 13, 2024·1m