Clinical Chemistry Podcast

Dr.

Bob Barrett treats lipoprotein(a) as a cardiovascular risk marker that matters, even though it is still far from routine practice.

This episode discusses transdermal GFR (TGFR), a new FDA-approved device for monitoring kidney function without serial blood draws.

Clinical Chemistry examines how the European Union's 2017 IVDR, effective in 2022, produced regulatory fragmentation around in-house diagnostic tests.

This episode explores the resurgence of syphilis, with Dr.

Massimo Mangiola compares molecular HLA matching to choosing the closest Yankees jersey to explain rejection risk.

This episode explores the limitations of population-based reference intervals in clinical lab testing and introduces personalized reference intervals based on stable homeostatic set points.

This episode features Dr.

An interview with Dr.

This episode discusses a Nature study on lithium as a potential preventive agent for Alzheimer's disease and its implications for clinical laboratories.

This episode discusses two studies: one on quantum machine learning for biomedical data and another on AI label feedback loops in clinical algorithm retraining.

This episode discusses new non-invasive blood tests for colorectal cancer screening and their potential impact on detection and mortality rates.

This episode presents two research studies: one on a novel method for detecting cancer-derived aneuploidies during prenatal cell-free DNA screening, and another on a culture-free lipidomics-based test for uropathogens.

The 300 nanograms-per-deciliter cutoff identified 22% of healthy men after assays shifted from immunoassay to mass spectrometry.

This episode discusses the updated Endocrine Society guidelines on vitamin D testing and their impact on clinical laboratories.

A clinical case study about diagnosing a rare thyroid condition with inappropriately normal TSH and elevated free thyroid hormones.

Point-of-care CYP2C19 testing can guide antiplatelet therapy in approximately one hour, but it cannot detect every relevant variant.

David McClintock explains why LORIS is currently a calculator, not a medical device.

This episode discusses new ASH guidelines recommending thrombophilia testing for unprovoked VTE and the challenges for clinical laboratories.

Jill Marin argues that genomic sequencing must protect a child across the entire life course, not only diagnose illness today.

This episode discusses a new perspective article on niacin's paradoxical increase in cardiovascular risk despite lowering cholesterol.

This episode discusses challenges in measuring estradiol with traditional methods and explores the potential of wearable biosensors for continuous, real-time monitoring.