TED Health is built around a recurring two-part interview format: a TED, TEDx, or TED-Ed talk on a health topic is presented first, then Dr. Shoshana Ungerleider interviews a physician or researcher who deepens or applies that talk's argument. Recurring subject areas include aging and longevity (biological age markers, social connection as a longevity factor), menopause and women's health, U.S. drug pricing and health policy, and mental health topics such as boredom, ADHD, and self-advocacy in medical settings. Guests are typically Harvard- or hospital-affiliated physicians and researchers, though the show also features non-clinical guests like stylist and author Stacey London discussing menopause and midlife identity. Some episodes are recorded live at the TED Conference in Vancouver rather than as remote interviews. Dr. Ungerleider draws on her own background as a physician, including her own experience with surgical menopause, to frame follow-up questions. The tone is educational and conversational rather than clinical or academic, with an emphasis on translating research into concrete takeaways or action steps for listeners. Episodes often cite specific studies, statistics, and named research programs (e.g., PORTAL at Brigham and Women's, University of Virginia boredom research) rather than speaking in generalities. Episode lengths vary from under 30 minutes for single-topic explainer-style episodes to nearly an hour for extended conference interviews. Listeners interested in evidence-based, TED-adjacent health content with a policy and self-advocacy angle are the core audience. The show is part of the TED Audio Collective and cross-promotes other TED podcasts such as How to Be a Better Human.