Stuff To Blow Your Mind is produced by iHeartPodcasts and hosted by Robert Lamb and Joe McCormick, who record as a two-person panel rather than bringing on outside interview guests. The core format alternates between standalone science-explainer episodes and serialized multi-part deep dives, such as a three-part series on disorientation in microgravity ('The Upside-Down') and a two-part history of goldfish domestication and biology ('Court of the Golden Fishes'). A recurring segment called Weirdhouse Cinema (also styled Weird House Cinema) shifts the format toward film history, covering kaiju movies, Shaw Brothers-era Hong Kong horror, and fantasy adaptations, with attention to production history and casting rather than conventional criticism. Listener-mail episodes revisit prior topics through audience questions, often chasing a single scientific or historical tangent. Subject matter regularly blends hard science, such as inner-ear physiology, deep-sea biology, and optics, with mythology and folklore, including yokai, cryptids, and regional legends, and with film and cultural history. Episode tone throughout is educational and exploratory rather than debate-driven or news-oriented. Episode length varies widely, from roughly 48 minutes for standard topic episodes to over 100 minutes for some Weirdhouse Cinema installments. The show cites academic papers, museum collections, and historical texts as sources for its claims. Some episodes carry a noticeable amount of network promotional content ahead of the main discussion. Listeners drawn to the overlap of science, folklore, and cult film history are the core audience for the show.