StarTalk Radio is an interview and panel-format show hosted by astrophysicist Neil deGrasse Tyson, recorded with one or more comic co-hosts present in nearly every episode. Chuck Nice and Gary O'Reilly are the two recurring co-hosts, functioning as an audience stand-in who ask clarifying questions and keep exchanges from becoming pure lecture. A distinct recurring format, 'Cosmic Queries,' pulls questions directly from listeners and Patreon supporters and uses them to structure episodes on topics like quantum measurement, entropy, and cosmic expansion; astrophysicist Charles Liu appears repeatedly in this format as a explainer. Outside Cosmic Queries, most episodes are single-guest interviews: mission scientists discussing specific space projects (an OSIRIS-REx sample scientist on the Bennu asteroid return), authors discussing the science behind their books (Andy Weir on 'Project Hail Mary,' Patricia Cornwell on forensic-accurate crime fiction), or subject-matter experts on topics adjacent to Tyson's core beat (a nutrition PhD on GLP-1 drugs and dietary guidelines, a forensic pathologist on autopsy procedure). The through-line across episodes is holding claims and popular narratives up against the underlying physical or biological evidence, whether the subject is a listener's question about black holes or a viral nutrition claim. Episodes run roughly 40 to 75 minutes and are released on a regular weekly schedule. The show suits listeners who want detailed scientific explanation delivered conversationally, with room for tangents into science fiction, true crime, and the personal histories of scientists. It is not a solo-narrated show or a strict news-of-the-week format; it is anchored by Tyson's presence in nearly every episode alongside a rotating cast of guests and a fixed pair of comic co-hosts.