Plain English with Derek Thompson is a twice-weekly interview show from The Ringer, hosted solely by Atlantic staff writer Derek Thompson. Each episode opens with Thompson laying out a headline claim or puzzle before bringing on a single guest to work through it in depth, rather than using a panel or rotating co-host format. Guests tend to be subject-matter specialists rather than celebrities: journalists and authors (Julia Belluz on ultra-processed food policy, Ryan Burge on religious-affiliation data), industry executives (Eli Lilly CEO David Ricks on GLP-1 drug development), and practitioners (Broadway producer John Johnson). Recurring subject areas include labor markets and economics, energy policy and its ties to AI infrastructure and geopolitics, pharmaceutical and nutrition science, and the entertainment business (Broadway, Hollywood). The show also covers neuroscience and aging, and occasionally turns to self-improvement and the philosophy of achievement. Conversations are grounded in cited studies, historical regulation, and named statistics, with Thompson frequently complicating a simple explanation into a more tangled one. Episodes typically run 45 to 70 minutes. The show periodically reruns past interviews under a 'Best Of' label. It suits listeners who want explainer-style journalism applied to current headlines rather than punditry or debate. Production is a straightforward two-person conversation with Thompson's framing at the open and close of each episode.