Root-cause health with a hard edge.
Paul Saladino MD podcast makes nutrition and chronic disease feel urgent, personal, and political. Episodes move quickly through gut testing, cholesterol debates, ultra-processed food, bees, honey, supplements, and the everyday systems the show frames as making people sick.
PRESS PLAY
Paul Saladino MD podcast is a rapid, argument-driven health show centered on nutrition, metabolism, toxins, and chronic disease. It treats the modern food environment as a major suspect. Episodes often begin with a vivid case, a provocative lab result, or a blunt claim, then expand into a larger critique of medical practice, processed food, pesticides, or the way doctors explain risk. The show does not linger in the middle. It prefers a clear thesis, repeated from several angles, with guests brought in to add stories, data points, and practical examples. Cholesterol is a major recurring battlefield, especially LDL, ApoB, plaque, insulin resistance, statins, and whether cardiovascular risk can be reduced to a single marker. Gut health is another anchor, with discussion of parasites, bacterial overgrowth, histamine sensitivity, detoxification, and functional medicine testing. Food quality comes up constantly. Ultra-processed foods, dyes, additives, glyphosate, seed oils, and childhood diets are framed as central drivers of poor health. The show also reaches beyond the plate, connecting honey authenticity, bee health, agriculture, family meals, and household exposures to a broader argument about environmental pressure on human health. Its style is energetic and informal. Technical terms appear often, but they are usually translated back into everyday language and tied to a concrete choice at the grocery store, doctor’s office, or dinner table. Sponsor reads and supplement promotion can take up noticeable space. The editorial stance is unmistakable: conventional medical advice misses root causes, and better health starts with food quality, metabolic context, and lower toxic load. Listeners drawn to forceful health arguments, animal-based nutrition, and skepticism toward standard dietary guidance will find plenty to work with. Listeners who want slow, balanced debate should expect a more one-directional ride.
Made for: For listeners who want energetic, strongly argued health conversations about food quality, chronic disease, metabolic markers, and environmental exposure. Best for people comfortable hearing medical and nutrition claims challenged aggressively.
What sets it apart: The show blends functional medicine interviews, animal-based nutrition arguments, food-policy outrage, and lab-marker debates into one fast-moving editorial lane. It stands out by connecting cholesterol, gut testing, pesticides, honey, family meals, and supplements to the same root-cause worldview.
Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. I hope you’ll join me on this journey.
Based on 6 episodes we listened to · September 2026
Paul Saladino turns contentious nutrition and cardiovascular questions into specific, plainly argued conversations anchored in foods, biomarkers, and environmental exposures.
Paul Saladino builds episodes around a firm thesis, then pursues it through pointed interviews or solo question-and-answer sessions. His recurring ground is nutrition and cardiovascular health, with sustained attention to food processing, cholesterol, insulin resistance,…
This is the show that makes your honey jar feel like an agricultural crime scene.
Press play if you want
Short reviews from the PlayNext desk, based on the episodes we processed.
A practical look at gut testing, histamine triggers, and the claims built around functional nutrition protocols.
Parasites, bacterial overgrowth, histamine sensitivity, and expansive gut testing give the episode its push and pull. Evan Brand draws on his functional nutrition background to make the case for a testing-led approach, moving through gut tests, oat panels, mycotoxin tests, and…
A pointed Washington conversation about chemical exposure, food quality, and calorie-focused thinking.
Glyphosate, food dyes, additives, preservatives, and ultra-processed food drive this PlayNext review of what Americans encounter through diet.
A pantry question expands into bee biology, honey adulteration, and the stakes of a livable planet.
Honey opens this episode into a wider health story, with Eric Mason of Save the Bee linking bee biology to agriculture, ecosystems, and everyday food.
The host asks what frozen blood samples might reveal about insulin resistance and plaque progression.
The host starts with people who feel healthier after changing their diets, only to hear from their doctors that their LDL has risen. He and cardiothoracic surgeon Philip Ovadia argue that cholesterol and ApoB readings need context when discussing heart disease.
A wide-ranging health conversation lands best when it returns to the shared meal.
Ultra-processed food anchors a broad discussion about American health, family meals, and what ends up in the grocery aisle. The host and guest trace a line from fewer shared meals to cheap, fast, accessible food, then move into grain-based products and the role of major U.S.
A compact FAQ-style map of Saladino's positions on fasting, gut inflammation, vegetables, meat, and dietary evidence.
Paul Saladino frames this single-episode FAQ around his core positions on fasting, low-carb and keto approaches, gut inflammation, vegetables, and whether meat contributes to cardiovascular disease, gout, or cancer.
Physique coaching with sharper practical detail.
The body, read as a message.
Wellness served with kitchen-table warmth.
Practical wellness, slowed down and made usable.
Paul Saladino uses this Paul Saladino MD episode as a high-level FAQ on insulin resistance, diabetes, meat, gout, cardiovascular disease, and cancer.
Dr.
Dr.
Paul Saladino promotes an animal-based diet and his supplement line, discussing the benefits of consuming testosterone from desiccated organs.
Dr.
70% of the average American child's diet is ultra-processed food, a statistic Sean Stevenson says drives chronic disease epidemics.
At the Animal Based Gathering in Costa Rica, Paul Saladino argues that eating saturated fat while avoiding seed oils can raise ApoB 20-30%, and that this matters less when fasting insulin is under 5 µIU/mL.
Paul Saladino and Evan Brand focus on GI Map testing, with Brand describing how he found Giardia, Cryptosporidium, and H.
“Obesity is not necessarily a failure of willpower,” and ultra-processed foods are engineered to “hijack your brain.”
A worker bee makes only "a twelfth of a teaspoon" of honey, but pollinates "thousands of flowers."
Paul Saladino and cardiothoracic surgeon Philip Ovadia discuss whether LDL-C and ApoB should be interpreted alongside insulin resistance, inflammation, particle size, and coronary imaging.