Keeper Chat takes one animal per episode and hands it to two people who describe themselves as former zookeepers. Fauna and Flora trade the introduction back and forth. Then they add a disclaimer that nothing they say reflects any organization, past, present or future. After the cue 'let's get grimy', the conversation takes off. Patrons often choose the animal, and supporting the show on Patreon can include the right to pick, along with bonus episodes and a Discord. The pair are candid about how much of each episode is actually about the animal. One intro promises three or four facts and calls the rest nonsense, and elsewhere they joke that the animal gets only a sliver of the airtime. When the facts come, they are specific and often odd. Female lice glue their eggs to the hair shaft with a secretion that hardens into a sheath, leaving an opening for the egg to breathe, and in hot tropical climates those eggs can sit as far as six inches down the hair. The crested coua of Madagascar is a weak flier with no fear of heights, and it has a third toe that flips around to help it grip in the canopy. Males and females look alike, while juveniles are paler, with a smaller crest and none of the turquoise around the eye. Kea no longer live on New Zealand's North Island, and the hosts link the bird's range to humans and to where mammalian predators live. Emperor tamarins live in groups run by a dominant female and her mate, and they form mixed foraging troops with another tamarin species, which the hosts act out as a trip to the mall. Between the facts, almost anything can come up. The pygmy falcon episode falls during National Zookeeper Week and veers into a muddle over how big the shark in 'The Meg' is supposed to be. The kea conversation stalls on the hosts' confusion about New Zealand's islands and where Papua New Guinea sits. They mock themselves constantly, from admitting they were never experts to joking about waking up dumber every day. The language is strong throughout, and some jokes turn crude and sexual. Sign-offs include the Patreon pitch, a pledge to give five dollars to a conservation group chosen by a patron for each rating and review, and the farewell 'smell you later'. In '213: Pigeon', the hosts tell listeners the show is ending and thank everyone who wrote in during their break. They also say the back catalog will stay up on podcast platforms.