Disease Du Jour is built for close listening by people who care about equine medicine in detail. Carly Sisson guides each episode around a defined veterinary subject, then lets the guest’s clinical and research experience shape the conversation. The result is measured and practical. Episodes have covered soft tissue injuries, intra-articular corticosteroids, performance horse nutrition, equine welfare, laminitis, prepurchase exams, field radiographs, and EOTRH. The show’s center of gravity is decision-making. When a tendon lesion is visible on ultrasound, the conversation asks when advanced imaging still matters. When corticosteroids are considered, the discussion turns to insulin dysregulation, point-of-care testing, documentation, and laminitis risk. When nutrition comes up, the focus is not just protein as a label, but amino acids, forage substitutes, hay cube size, and the different needs of individual equine athletes. Welfare is handled with similar specificity. Episodes look at behavior, learned helplessness, freedom to move, access to other horses, forage, turnout, and how these factors affect outcomes. Diagnostic imaging gets grounded in the realities of the field, where equipment, environment, and horse cooperation all shape what a veterinarian can actually capture. Dentistry and prepurchase exams receive the same procedural attention. Disease Du Jour does not flatten equine medicine into simple rules. It gives listeners the vocabulary and context to understand why cases differ, where uncertainty remains, and what current research may clarify next. The show is especially valuable for equine veterinarians, veterinary students, performance-horse professionals, and highly engaged owners who want clinical reasoning rather than general horse-care advice.