Biotech strategy from the people building it.
The gist
Biotech 2050 tracks the business and science decisions shaping modern biotech. Episodes pair executive career arcs with detailed discussion of clinical programs, financing discipline, therapeutic strategy, and the operational realities behind new medicines.
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About Biotech 2050 Podcast
Biotech 2050 is built around long-view conversations with people making consequential bets in biotech. The show favors executives, founders, and investors who can connect a therapeutic thesis to the practical machinery of building a company. It is not a news roundup. It is more like a running field guide to what biotech leaders are prioritizing, avoiding, and trying to prove. Recent episodes move across respiratory disease, addiction medicine, immunology, oncology, rare disease, cell therapy, CRISPR, and private-market investing. The scientific material is specific. Guests talk about receptor binding, companion diagnostics, autoimmune indications, off-the-shelf cell therapy, tRNA platforms, uveitis, and CAR T design. The business material is just as present. Capital discipline, hiring, commercialization, trial enrollment, supply-chain complexity, and cross-border constraints all recur. That combination gives the show its shape. A typical conversation starts with the guest's path into biotech, then narrows into the strategic decisions behind a program or platform. The pacing is professional and direct. Hosts ask for the differentiation, the indication choice, the development risk, and the market reality. Patient impact is a steady thread, especially in discussions of rare disease, alcohol addiction, autoimmune disease, and conditions with limited treatment options. The show also returns often to how biotech companies survive difficult market environments. Focus matters. So do capital reserves, tolerability, dosing convenience, and the ability to tell a credible clinical story. For listeners inside the industry, those details make the interviews useful beyond the headline science. For biotech-curious listeners, the show explains why a promising therapy is never just a molecule or a platform. It is also a test of timing, evidence, operations, and judgment. Biotech 2050 works best for people who want to hear the future of medicine discussed by the people trying to finance it, test it, and bring it to patients.
Made for: Designed for biotech operators, life-science investors, founders, clinicians, and technically curious listeners who want executive-level context on drug development and platform companies.
What sets it apart: The show keeps science, financing, and execution in the same frame. Its interviews are grounded in company decisions rather than broad futurism.
In their own words
Biotech2050 Podcast is a think tank chronicling the disruptions changing the biotech industry over the next 50 years.
Why you'd press play
Biotech optimism meets trial enrollment, and you get the strategy after the scientific applause.
Press play if you want
- to hear CEOs explain why one therapy, indication, or hiring bet deserves scarce capital
- the operational thinking behind clinical trials and a cheek-swab companion diagnostic
Talks about
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Episodes
- 1
Pioneering Advances in Cell Therapy: Kristin Yarema, President & CEO of Poseida Therapeutics
·39m - 2
Sheila Gujrathi, MD on Leadership, Biotech Innovation & The Mirror Effect for Women Leaders
·40m - 3
Fred Aslan, Artiva CEO, on Cell Therapy’s Next Wave, RA Trials & Scalable NK Platforms
·25m - 4
Michelle Werner, CEO of Alltrna, on tRNA Platforms, Rare Disease & Drug Innovation
·27m - 5
Brian Hilberdink on Boehringer’s U.S. Growth, AI & Pharma’s Next Frontier
·22m - 6
Johan Luthman, Lundbeck EVP R&D, on Rebuilding Neuroscience Pipelines & Drug Discovery
·31m - 7
Christophe Bourdon, LEO Pharma CEO, on Dermatology Innovation, Rare Disease & Scalable Growth
·13m - 8
Matt Gline, Roivant Sciences CEO, on Clinical Breakthroughs, Capital Discipline & Building Biotech
·34m - 9
Jay Hartenbach, President & COO, Diakonos Oncology on Reprogramming Cancer Immunity Breakthrough
·28m - 10
John Lepore, CEO & President - ProFound Therapeutics, on Proteome, AI, & Bold First-in-Class Drugs
·35m - 11
Jason Kelly - Ginkgo Bioworks CEO and Co-Founder on Automation, AI Data & Biotech’s Reset
·40m - 12
Arun Swaminathan: Coya CEO on Neuroinflammation, BD Strategy & Patient-Driven Biotech
·37m - 13
How Nimbus CEO Abbas Kazimi Builds Resilient Pipelines Through Culture, Rigor & Smart Bets
·43m - 14
Foresite Capital’s Jim Tananbaum on Biotech Cycles, AI Breakthroughs & Long-Term Value
·23m - 15
Geoffrey Duyk, Grove Biopharma CEO, on Polymer Breakthroughs, Intractable Targets & Biotech's Future
·41m - 16
Syndax CEO Michael Metzger on Bold Leadership, Dual Drug Launches & Redefining Cancer Care
·27m - 17
Co-creating Breakthroughs in R&D: Paul Biondi (Flagship) & Uli Stilz (Novo Nordisk)
·39m - 18
Kevin Caldwell, Ossium Health CEO, on Cell Therapy, Vertical Integration & Immune Healthspan
·36m - 19
Rewriting Cancer: AmirAli Talasaz, Co-CEO of Guardant Health, on Liquid Biopsy, Data & Biotech Grit
·39m - 20
Terns CEO Amy Burroughs on CML Innovation, Obesity Drug Breakthroughs & Leading Biotech Forward
·23m - 21
Jeremy Bender, Day One CEO, on Transforming Pediatric Cancer Care & Leading Biotech with Purpose
·41m - 22
Ahmed Mousa, Vicore CEO, on IPF Breakthroughs, AI-Powered Drug Discovery & Global Biotech Leadership
·17m - 23
Curran Simpson, President & CEO of REGENXBIO, on Gene Therapy, Strategy & Patient-Centered Impact
·28m - 24
Sergey Jakimov, Founding Partner at LongeVC, on Pragmatic Longevity Investing & Biotech Innovation
·32m - 25
Dr. Howard Fillit & Mark Roithmayr of ADDF on Alzheimer’s Innovation, Funding & Biomarkers
·42m - 26
Stacy Lindborg, Imunon President & CEO, on Bold Biotech, IL-12 Immunotherapy & Phase 3 Trials
·18m - 27
Stephanie Sirota, CBO & Partner at RTW Investments, on Biotech Investing, Policy & Bold Bet Building
·25m - 28
Steve Tregay on Leading Mission BioCapital as Managing Partner & Fueling Early-Stage Biotech
·42m - 29
Neil F. McFarlane, President & CEO of Zevra Therapeutics, on Leading Rare Disease Innovation
·36m - 30
Raj Devraj, President & CEO - Rectify Pharma, on Drug Discovery, Biotech Breakthroughs & Growth
·34m - 31
Liam Killingstad on How Family Offices Quietly Fuel Biotech’s Boldest Innovations
·59m - 32
Clare Terlouw, Head of LifeArc Ventures, on Bridging Biotech’s Funding Gap & Investing for Impact
·43m - 33
AI, Biotech, & Venture Capital: Alex Bangash, Founder of Transpose, on Future of Startup Investing
·24m - 34
Empowering Neurodivergent Innovators: Chad Belinsky on Impact, Mentorship, and Atypical Path
·36m - 35
Biotech Venture Investing with Narayan Chowdhury, Co-Founder of Franklin Park LLC
·28m - 36
David Meeker, CEO of Rhythm Pharmaceuticals, on Rare Disease Breakthroughs & Biotech’s Future
·58m - 37
Adial CEO Cary Claiborne on Treating Alcohol Addiction with Genetics
·14m - 38
Bharatt Chowrira, CEO & Eric Elenko, CoFounder & President of PureTech on Biotech Growth
·45m - 39
Rob Williamson, CEO of Triumvira, on Biotech’s High-Stakes Path and Cell Therapy Innovations
·24m - 40
Gene Mack, Interim CEO & CFO of Gain Therapeutics: Leading the Charge in Parkinson's Breakthroughs
·32m - 41
Revolutionizing Heart Health: Bitterroot Bio’s Bold Vision with CEO Pavan Cheruvu
·43m - 42
Inside the Journey of Abcuro: CEO Alex Martin on Leadership, IBM, and the Future of Biotech
·37m - 43
Precision Neuroscience Breakthroughs: Abe Ceesay, CEO of Rapport Therapeutics I Future of Biotech
·47m - 44
Dr. Dave Bearss, Co-Founder & CEO of Halia, on Pioneering Genetic Discoveries to Defeat Alzheimer’s
·36m - 45
Breaking Biotech Barriers: Avidity President & CEO Sarah Boyce on RNA’s Next Frontier
·35m - 46
Advancing Drug Discovery with Cutting-Edge AI & Team Synergy: Fabrice Chouraqui, CEO of Cellarity
·32m - 47
Redefining Dementia Care: CervoMed's Bold Journey with CEO John Alam
·25m - 48
From Banking to Biotech: Renée Aguiar-Lucander, CEO of Calliditas, on Rare Disease Innovation
·31m - 49
Autoimmune Innovations: Insights from Marshall Fordyce, Founder & CEO, Vera Therapeutics on Biotech
·33m - 50
Transforming Gene Therapy: Exclusive Insights from Zandy Forbes, President & CEO of MeiraGTx
·50m - 51
Biotech Breakthroughs: Jeb Keiper, CEO of Nimbus Therapeutics, Discusses Their Innovative Journey
·35m - 52
Revolutionizing Proteomics: Sujal Patel, Co-Founder & CEO of Nautilus, on Drug Development
·37m - 53
Exploring Neuroscience, Psychiatry, & Rare Diseases, Bruce Leuchter, President & CEO, Neurvati
·51m - 54
Transformative Oncology Innovations, Ken Keller, President & CEO, Daiichi Sankyo, Inc.
·28m - 55
Strategic Leadership and Autoimmune Breakthroughs, Praveen Tipimeni, CEO
·34m - 56
Innovative Approaches to Cancer Therapies, Robert Ang, President and CEO
·30m - 57
Tech-Biotech Convergence, Growth, and Global Lessons, Vik Bajaj, Co-founder and CEO
·31m - 58
Advancing and Revolutionizing Sickle Cell Treatment, Ted Love, Chair and BOD
·27m - 59
Demystifying Drug Discovery, Ray Stevens, CEO, Structure Therapeutics
·32m - 60
Navigating The Evolving Landscape of Inflammation Research, Scott Megaffin, CEO, Adiso Therapeutics
·28m - 61
Biotech's Game Changers & Revolutionizing Therapeutics, Dr. Mammen, CEO, FogPharma
·51m - 62
The Race to Cure Untreatable Cancers, Ken Galbraith, Chair and CEO, Zymeworks
·41m - 63
Innovation in Precision Therapies for CNS Diseases, Craig Chambliss, Co-Founder and CEO, Neurelis
·37m - 64
Unlocking Genetic Medicine's Full Potential, Tuyen Ong, CEO, Ring Therapeutics
·23m - 65
Aging Biology and The Power of Human Data, Kristen Fortney, Co-Founder and CEO, BioAge
·27m - 66
The Intersection Of Tech and Biotech, Chris Gibson, Co-Founder & CEO, Recursion
·40m - 67
Psychedelics, Longevity, and Wellbeing, Christian Angermayer, Founder, Apeiron Investment Group
·46m - 68
Navigating Platform vs Product Tension, David Kirn, Co-Founder & CEO, 4DMT
·34m - 69
Adapting Through Disruption in Biotech, David Esposito, President & CEO, ONL Therapeutics
·26m - 70
Overcoming Capital Challenges in Biotech, Jak Knowles, President & CEO, Affini-T Therapeutics
·26m - 71
A novel approach to advancing breast cancer therapy, Sean Bohen, President & CEO, Olema Oncology
·20m - 72
The promise of precision oncology, Troy Wilson, President & CEO, Kura Oncology
·33m - 73
Next-gen gene editing, Keith Gottesdiener, President & CEO, Jeremy Duffield, CSO, Prime Medicine
·41m - 74
Developing medicines for broad populations of cancer patients, Brett Hall, CSO, Immuneering
·41m - 75
Harnessing the power of microglia, Ivana Magovčević-Liebisch, President & CEO, Vigil Neuroscience
·26m - 76
Revolutionizing eyecare treatment, Bobak Azamian, CEO & Chairman, Tarsus Pharmaceuticals
·27m - 77
Targeting validated drivers of cancer, Nima Farzan, CEO, Kinnate Biopharma
·30m - 78
Advancing bold therapies for neuronal health, Mark Litton, President & CEO, Athira Pharma
·29m - 79
Pioneering RNA editing to deliver the future of medicine, Ram Aiyar, President & CEO, Korro Bio
·28m - 80
Unlocking the technological potential of biology, Seemay Chou, Co-Founder & CEO, Arcadia Science
·44m - 81
Pioneering tRNA therapeutics, Michelle Werner, CEO, Alltrna & CEO-Partner, Flagship Pioneering
·30m - 82
Breaking new ground in the treatment of fibrosis, Bernard Coulie, President & CEO, Pliant Tx
·33m - 83
Transforming medicine through precision epigenomic control, Mahesh Karande, Pres. & CEO, Omega Tx
·30m - 84
Catalyzing the next generation of mRNA medicines, Joseph Payne, Founder, Pres. & CEO, Arcturus Tx
·29m - 85
Advancing muscle biology, Robert Blum, Pres. & CEO, & Fady Malik, EVP, Research & Dev., Cytokinetics
·30m - 86
Transforming the treatment of neuromuscular diseases, James McArthur, CEO, PepGen
·28m - 87
Conquering new frontiers in cell therapy, Paul Lammers, CEO, Triumvira Immunologics
·34m - 88
Next-gen immunotherapies for cancer, Andrew Scharenberg, Co-founder & CEO, Umoja Biopharma
·33m - 89
Transforming medicine through non-viral gene therapy, Theresa Heah, CEO, Intergalactic Tx
·20m - 90
Transforming diseased cells into coordinators of cure, Volker Herrmann, President & CEO, Sonata Tx
·35m - 91
Breaking barriers in rare genetic mitochondrial diseases, Greg Flesher, Pres. & CEO, Reneo
·27m - 92
Correcting abnormal gene expression in oncology, Adrian Gottschalk, Pres. & CEO, Foghorn Tx
·31m - 93
Epigenetic therapies for organ injury & chronic liver diseases, Jim Brown, Pres. & CEO, DURECT
·29m - 94
New vision for preventing & curing age-related diseases, James Peyer, Founder & CEO, Cambrian Bio
·29m - 95
Revolutionizing T-cells for solid tumor cell therapies, Gary Lee, CSO, Lyell Immunopharma
·29m - 96
Mobilizing the immune system to combat disease, Liang Schweizer, Founder & CEO, HiFiBiO Tx
·31m - 97
BIO Special: New vision for immunotherapy, Detlev Biniszkiewicz, Founder & CEO, NextPoint Tx
·34m - 98
BIO Special: Advancing kidney disease care, Eric Dobmeier, President & CEO, Chinook Tx
·41m - 99
BIO Special: Advancing heart disease treatment, Faraz Ali, CEO, Tenaya Therapeutics
·38m - 100
Revolutionizing CAR T with CRISPR: Rachel Haurwitz, President & CEO of Caribou Biosciences
Rachel Haurwitz, CEO of Caribou Biosciences, discusses her early work on CRISPR and the company's efforts to revolutionize CAR T-cell therapy using CRISPR gene editing.
·26m - 101
Barry Quart, CEO of Connect Biopharma, on Asthma Innovation & Biotech Leadership
Hidden gemCEO Barry Quart discusses asthma innovation, biotech leadership, and his experience bringing nine drugs to FDA approval.
Apr 16, 2026·23m·1 clip - 102
Adial CEO Cary Claiborne on Treating Alcohol Addiction with Genetics
Hidden gemAdial CEO Cary Claiborne discusses treating alcohol addiction with genetics and his career journey in biotech.
Mar 6, 2026·14m·1 clip - 103
Sheila Gujrathi, MD on Leadership, Biotech Innovation & The Mirror Effect for Women Leaders
Sheila Gujrathi describes leaving academic medicine after training at the Brigham, Stanford, and UCSF, joining McKinsey, and entering Genentech in 2002 before moving into biotech leadership.
Mar 5, 2026·40m·2 clips - 104
Fred Aslan, Artiva CEO, on Cell Therapy’s Next Wave, RA Trials & Scalable NK Platforms
Hidden gemBiotech 2050 Podcast host Alok Taiyi interviews Fred Aslan, CEO of Artiva, about allogeneic NK-cell therapy, autoimmune disease, and the next stage of cell-therapy development.
Feb 11, 2026·25m·1 clip - 105
Michelle Werner, CEO of Alltrna, on tRNA Platforms, Rare Disease & Drug Innovation
Michelle Werner, CEO of Alltrna, discusses her background in pharma, her shift to rare disease after her child's diagnosis, and the potential of tRNA platforms for drug innovation.
Feb 10, 2026·27m - 106
Brian Hilberdink on Boehringer’s U.S. Growth, AI & Pharma’s Next Frontier
Jan 28, 2026·22m - 107
Johan Luthman, Lundbeck EVP R&D, on Rebuilding Neuroscience Pipelines & Drug Discovery
Jan 27, 2026·31m - 108
Christophe Bourdon, LEO Pharma CEO, on Dermatology Innovation, Rare Disease & Scalable Growth
Jan 20, 2026·13m - 109
Matt Gline, Roivant Sciences CEO, on Clinical Breakthroughs, Capital Discipline & Building Biotech
Hidden gemMatt Gline says Roivant’s sale of an ATTO1A antibody to Roche for about $7 billion, with about $5 billion returning to Roivant, changed the company’s capital profile and forced a sharper focus on execution.
Dec 17, 2025·34m·2 clips - 110
Jay Hartenbach, President & COO, Diakonos Oncology on Reprogramming Cancer Immunity Breakthrough
Dec 10, 2025·28m - 111
John Lepore, CEO & President - ProFound Therapeutics, on Proteome, AI, & Bold First-in-Class Drugs
Dec 3, 2025·35m - 112
Jason Kelly - Ginkgo Bioworks CEO and Co-Founder on Automation, AI Data & Biotech’s Reset
Nov 25, 2025·40m - 113
Arun Swaminathan: Coya CEO on Neuroinflammation, BD Strategy & Patient-Driven Biotech
Nov 20, 2025·37m - 114
How Nimbus CEO Abbas Kazimi Builds Resilient Pipelines Through Culture, Rigor & Smart Bets
Nov 13, 2025·43m - 115
Foresite Capital’s Jim Tananbaum on Biotech Cycles, AI Breakthroughs & Long-Term Value
Nov 5, 2025·23m - 116
Geoffrey Duyk, Grove Biopharma CEO, on Polymer Breakthroughs, Intractable Targets & Biotech's Future
Oct 23, 2025·41m - 117
Syndax CEO Michael Metzger on Bold Leadership, Dual Drug Launches & Redefining Cancer Care
Oct 8, 2025·27m - 118
Co-creating Breakthroughs in R&D: Paul Biondi (Flagship) & Uli Stilz (Novo Nordisk)
Sep 30, 2025·39m - 119
Kevin Caldwell, Ossium Health CEO, on Cell Therapy, Vertical Integration & Immune Healthspan
Aug 21, 2025·36m - 120
Rewriting Cancer: AmirAli Talasaz, Co-CEO of Guardant Health, on Liquid Biopsy, Data & Biotech Grit
Aug 14, 2025·39m - 121
Terns CEO Amy Burroughs on CML Innovation, Obesity Drug Breakthroughs & Leading Biotech Forward
Jul 31, 2025·23m - 122
Jeremy Bender, Day One CEO, on Transforming Pediatric Cancer Care & Leading Biotech with Purpose
Jul 23, 2025·41m - 123
Ahmed Mousa, Vicore CEO, on IPF Breakthroughs, AI-Powered Drug Discovery & Global Biotech Leadership
Jul 16, 2025·17m - 124
Curran Simpson, President & CEO of REGENXBIO, on Gene Therapy, Strategy & Patient-Centered Impact
Jul 8, 2025·28m - 125
Sergey Jakimov, Founding Partner at LongeVC, on Pragmatic Longevity Investing & Biotech Innovation
Jul 2, 2025·32m - 126
Dr. Howard Fillit & Mark Roithmayr of ADDF on Alzheimer’s Innovation, Funding & Biomarkers
Jun 17, 2025·42m - 127
Stacy Lindborg, Imunon President & CEO, on Bold Biotech, IL-12 Immunotherapy & Phase 3 Trials
May 14, 2025·18m - 128
Stephanie Sirota, CBO & Partner at RTW Investments, on Biotech Investing, Policy & Bold Bet Building
May 8, 2025·25m - 129
Steve Tregay on Leading Mission BioCapital as Managing Partner & Fueling Early-Stage Biotech
Apr 3, 2025·42m - 130
Neil F. McFarlane, President & CEO of Zevra Therapeutics, on Leading Rare Disease Innovation
Mar 26, 2025·36m - 131
Raj Devraj, President & CEO - Rectify Pharma, on Drug Discovery, Biotech Breakthroughs & Growth
Mar 20, 2025·34m - 132
Revolutionizing CAR T with CRISPR: Rachel Haurwitz, President & CEO of Caribou Biosciences
Hidden gemRachel Haurwitz, CEO of Caribou Biosciences, discusses her early work on CRISPR and the company's efforts to revolutionize CAR T-cell therapy using CRISPR technology.
Mar 11, 2025·26m·1 clip - 133
Liam Killingstad on How Family Offices Quietly Fuel Biotech’s Boldest Innovations
Mar 6, 2025·59m - 134
Clare Terlouw, Head of LifeArc Ventures, on Bridging Biotech’s Funding Gap & Investing for Impact
Feb 26, 2025·43m - 135
AI, Biotech, & Venture Capital: Alex Bangash, Founder of Transpose, on Future of Startup Investing
Feb 20, 2025·24m - 136
Empowering Neurodivergent Innovators: Chad Belinsky on Impact, Mentorship, and Atypical Path
Feb 12, 2025·36m - 137
Biotech Venture Investing with Narayan Chowdhury, Co-Founder of Franklin Park LLC
Narayan Chowdhury, co-founder of Franklin Park, discusses biotech venture investing from the limited partner perspective.
Feb 6, 2025·28m - 138
David Meeker, CEO of Rhythm Pharmaceuticals, on Rare Disease Breakthroughs & Biotech’s Future
Jan 29, 2025·58m - 139
Pioneering Advances in Cell Therapy: Kristin Yarema, President & CEO of Poseida Therapeutics
Nov 20, 2024·39m - 140
Bharatt Chowrira, CEO & Eric Elenko, CoFounder & President of PureTech on Biotech Growth
Nov 13, 2024·45m - 141
Rob Williamson, CEO of Triumvira, on Biotech’s High-Stakes Path and Cell Therapy Innovations
Nov 6, 2024·24m - 142
Gene Mack, Interim CEO & CFO of Gain Therapeutics: Leading the Charge in Parkinson's Breakthroughs
Oct 30, 2024·32m - 143
Revolutionizing Heart Health: Bitterroot Bio’s Bold Vision with CEO Pavan Cheruvu
Oct 23, 2024·43m - 144
Inside the Journey of Abcuro: CEO Alex Martin on Leadership, IBM, and the Future of Biotech
Oct 17, 2024·37m - 145
Precision Neuroscience Breakthroughs: Abe Ceesay, CEO of Rapport Therapeutics I Future of Biotech
Oct 11, 2024·47m - 146
Dr. Dave Bearss, Co-Founder & CEO of Halia, on Pioneering Genetic Discoveries to Defeat Alzheimer’s
Oct 4, 2024·36m - 147
Breaking Biotech Barriers: Avidity President & CEO Sarah Boyce on RNA’s Next Frontier
Sep 19, 2024·35m - 148
Advancing Drug Discovery with Cutting-Edge AI & Team Synergy: Fabrice Chouraqui, CEO of Cellarity
Fabrice Chouraqui, CEO of Cellarity, discusses his career journey in biotech and the role of AI and team synergy in advancing drug discovery.
Aug 28, 2024·32m - 149
Redefining Dementia Care: CervoMed's Bold Journey with CEO John Alam
CEO John Alam discusses his background in medicine and biotech, leading to his role at CervoMed, focusing on translational medicine and drug development for dementia care.
Aug 15, 2024·25m - 150
From Banking to Biotech: Renée Aguiar-Lucander, CEO of Calliditas, on Rare Disease Innovation
Aug 6, 2024·31m