Reversing age with Food & Medicine!

·42 min·4 clips

Dr. Carl Goldkamp reveals how the ketogenic diet saved his life and transformed his health journey.

Dr. Carl Goldkamp introduces his podcast by sharing how the ketogenic diet saved his life and inspired his focus on keto-related health topics. He transitions to discussing a recent study titled 'Potential Reversal of Epigenetic Age Using a Diet and Lifestyle Intervention,' published in the Journal of Aging. The study involved 18 men aged 50-72 who followed a specific diet for nine weeks, including 11 ounces of liver per week, 7-10 omega-3 enriched eggs, and vegetables like dark leafy greens and cruciferous veggies. Participants also took a probiotic and a phytonutrient drink, exercised 30 minutes five days a week, and slept seven hours nightly. Results showed an average epigenetic age reduction of 1.96 years, measured using the Horvath methylation clock. Goldkamp explains epigenetics through historical examples like the Dutch Hunger Winter, where starvation led to mental health issues passed across generations, and the Överkalix study in Sweden, which showed similar transgenerational effects. He references Dr. Randy Jirtle's 2003 mouse studies, where methyl donors like B vitamins reversed obesity and cancer in agouti mice, but notes that synthetic folic acid can increase cancer risk. The episode contrasts nutrient deficiency in modern diets with the study's whole-food approach, linking it to rising chronic diseases. Goldkamp discusses healthspan versus lifespan, noting the average American has 16 years of poor health before death, and argues that addressing deficiencies through diet can extend healthy years. He touches on exercise benefits, such as improved methylation and glutathione production, and connects lifestyle factors to mental health trends during the pandemic. The episode concludes with a call for listener questions and promotion of his Facebook group.

As heard by us

A clear, conversational look at methylation, gene expression, and the Horvath clock's view of aging.

Dr. Carl Goldkamp walks through aging by way of the Horvath methylation clock, using genome data to explain methylated genes as paused rather than broken.

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Why you'd press play

Press play when keto leads you into genetics, methylation, and the Horvath clock.

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