Nadie Sabe Nada is a two-hander, improvised talk-comedy show rather than a scripted or interview format: co-hosts Andreu Buenafuente and Berto Romero riff off each other, off a live studio audience, and off listener submissions with no fixed topic list. Each episode is loosely structured around a title bit (a mishearing, an object, a phrase) that the hosts spiral outward from into tangents, games, and invented lore. Recurring elements include audience Q&A and 'guess' games played live in the studio, parody characters the hosts voice themselves (a fictional Ferran Adrià, Andreu's 'Silver Balloon,' Berto's alter-ego bits), and callback jokes that span multiple seasons. Guests are rare; when named figures appear they tend to be public personalities referenced within a bit (a chef, a musician, a director) rather than formal sit-down interviewees. The hosts frequently narrate stories from their own touring, television, and film work, folding real career updates and awards recaps into the comedic flow. Compilation episodes labeled 'Recopilación' periodically resurface highlights from prior seasons, including season-opener retrospectives. The tone throughout is absurdist and self-aware, with the hosts often mocking the format of radio and podcasting itself mid-episode. It is aimed at listeners already comfortable with rapid-fire, referential Spanish-language humor rather than newcomers looking for a structured topic breakdown. Production is a live recording with a studio audience, later cut down into podcast-length episodes of roughly 50 minutes. Listeners who enjoy long-running in-jokes, invented characters, and loose improvisation over tightly produced segments are the core audience.