Math Mutation treats mathematics as a place where ordinary assumptions fail in interesting ways. Eric Seligman does not frame math as homework or spectacle. He frames it as a sequence of puzzles with consequences. A bathroom tile can lead to the Einstein tile problem, aperiodic tilings, quasicrystals, and the work of Smith, Myers, Kaplan, and Goodman-Strauss. A joke about proof by intimidation can become a clear distinction between legitimate mathematical shorthand and hand-waving. A casino story can expose the difference between maximizing one kind of chance and making a financially sensible decision. The show is especially good at starting from a familiar object. Floors, drinks, smartphones, books, drill bits, and coin flips all become entry points. The explanations usually stay conversational, but they do not flatten the subject into trivia. There is room for real terminology, from curves of constant width to formal verification, with examples chosen to make the term do visible work. History also matters here. John Kerich's prison-camp coin-flip experiment is presented as both a probability demonstration and a reminder that simple data collection meant something different before everyday computing. Translation receives similar treatment, moving from Douglas Hofstadter's writing to Nelson Rodriguez Chartrand's Spanish memoir and the problem of carrying intention across languages. The show has a dry, lightly amused tone. It is comfortable with jokes, puns, and sidetracks, but the point is almost always explanatory. The pacing is modest rather than flashy. Episodes feel like a mathematically curious person noticing something strange, reading around it, and returning with a compact tour. That makes Math Mutation useful for listeners who enjoy paradoxes, odd histories, and applications that make abstract math suddenly concrete. It is not a lecture series in disguise. It is a recurring reminder that mathematics keeps turning up in places that seem, at first glance, barely mathematical at all.