Cardiovascular papers, translated through the lab bench.
Discover CircRes turns Circulation Research issues into guided editorial briefings. Dr. Cindy St. Hilaire previews selected papers, then slows down for detailed conversations about featured cardiovascular biology studies.
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Discover CircRes is a close-reading show for the American Heart Association's journal Circulation Research. Dr. Cindy St. Hilaire introduces recent issue highlights, then centers each episode on a featured article conversation. The format is direct. A paper is named, its biological problem is set up, and the interview turns toward mechanism, methods, and interpretation. Recent episodes move across atherosclerosis, endothelial signaling, arterial calcification, lung injury, right heart remodeling, hypertension, and cardiac hypertrophic growth. The vocabulary is unapologetically scientific. FOXO-1, KLF2, KLF4, extracellular vesicles, PIK5, GC1, STAT3, D-dimers, fibrinogen, and single-cell RNA sequencing appear as practical tools for explaining what a study is trying to prove. The show is strongest when it asks how the research path actually formed. A guest may explain how literature on brown adipose tissue led toward extracellular vesicles. Another discussion may separate blood stasis, platelet activation, and thrombus formation in a lung model. A conversation about estrogen and GC1 turns on why an ovorectomy model suited the question being asked. The questions often stay close to experimental design. They ask what a mouse model enabled, how fluorescence tracked delivery, where a pathway first became interesting, and what uncertainty remains around cell-state labels. That gives the show a behind-the-paper quality without drifting into personality-first storytelling. It is polished but not slick. The pacing assumes comfort with cardiovascular biology, yet the host regularly translates why a pathway or model matters before returning to the details. Article highlights broaden the frame beyond the featured interview, so one episode can touch multiple studies before narrowing in. The recurring center is cardiovascular mechanism: how cells sense stress, communicate, remodel, inflame, calcify, protect tissue, or fail under disease pressure. Discover CircRes suits research-minded listening rather than casual wellness browsing. It offers a structured way to follow what recent CircRes papers are asking and how their authors reason through the evidence.
Made for: Suits a listener who wants cardiovascular biology at research depth, with article context and author discussion rather than general heart-health advice. It fits listeners who are comfortable with molecular pathways and experimental models.
What sets it apart: Discover CircRes is tied tightly to Circulation Research issues, so its editorial shape comes from journal articles rather than open-ended science news. Its distinction is the blend of paper highlights, author conversation, and practical attention to how cardiovascular experiments are built.
Each 15-minute podcast will provide an overview of the issue's contents and relevant news in the field of basic/translational cardiovascular biology followed by an in-depth discussion of a featured article. This discussion will pull opinions from the podcast hosts, editorial team, research leaders and authors – both the corresponding authors as well as the trainee(s). We will provide lively discussions that give the listener a behind the scenes look at how science gets done and the implications of these fascinating discoveries.
Dr. Cindy St. Hilaire gets you from cardiac protection to fluorescent mice tracking its messengers.
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Short reviews from the PlayNext desk, based on the episodes we processed.
A focused tour from precision gene editing in heart failure to FOXO1, endothelial flow, and atherosclerosis.
Discover CircRes brings together two connected layers of cardiovascular research: a targeted CRISPR-Cas9 adenine base-editing strategy designed to disable PKC-alpha in heart failure, and a broader look at how endothelial cells react to blood flow in atherosclerosis.
A cardiovascular research episode links sex-related plaque findings with work on brain-heart signaling and cardiac protection.
Discover CircRes brings together two strands of cardiovascular research: a clinical look at fibrous atherosclerotic plaques and a lab-focused discussion of cardiac protection.
A focused review of arterial calcification research, with a careful look at how vascular smooth muscle cells may shift identity.
Discover CircRes moves through cardiovascular research from two Circulation Research issues, then settles into a focused discussion of arterial calcification.
A careful cardiovascular research discussion on how lung thrombosis may protect injured tissue.
This Discover CircRes episode opens with article highlights from the January 2 and 16 issues of Circulation Research, then settles into a narrower problem in lung injury: whether thrombosis can sometimes protect tissue rather than simply harm it. Dr. Cindy St.
A compact cardiovascular research roundup turns toward estrogen, nitric oxide, and right heart remodeling.
Discover CircRes moves from a brisk tour of the December 5 issue into a more focused look at estrogen-linked signaling and its possible role in protecting the right heart during remodeling. The CPVT highlight on Hamilton et al.
A focused look at cellular cleanup, membrane structure, and how heart cells direct growth.
Discover CircRes treats a journal issue roundup as a brisk guided tour through cardiovascular disease at the cellular level. It moves from atherosclerosis, where macrophage DNases help clear harmful neutrophil extracellular traps, to work on the beta-4 spectrin-STAT3 complex and…
Oncology evidence translated into clinical decisions.
Critical care evidence, carefully talked through.
Clinical research, reduced to its practical signal.
Dr.
Discover CircRes March 2026 pairs four Circulation Research highlights with an interview on leptin-driven brown fat-heart crosstalk.
Discover CircRes February 2026 opens with Circulation Research highlights on CERC-ZB-TB44, OLFR2 in abdominal aortic aneurysm, neuratinib repurposing, and CD34-positive fibroblast progenitors in heart-transplant fibrosis.
Discover CircRes January 2026 pairs four January issue highlights with a detailed interview on sepsis-induced acute lung injury and endothelial ALOX15.
Discover CircRes December 2025 pairs three Circulation Research highlights with a right-heart-remodeling interview led by Dr.
Discover CircRes November 2025, hosted by Dr.
Discover CircRes October 2025 highlights four Circulation Research studies before interviewing Camila Venceslau and Liana Pernomian about OSK partial reprogramming in hypertensive mice.
Discover CircRes September 2025 features Cindy St.
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This episode of Discover Circ Res highlights recent articles from Circulation Research, including a study on perivascular fibrosis mediated by KLF10/IL9 signaling in T-cells and research on flow-induced suppression of endothelial-mesenchymal transition in atherosclerosis.
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