Clueston takes real crimes from Houston and the surrounding Gulf Coast and runs them through a two-person conversation. Kat is the host, and she does the research. Charles is the other voice at the microphone, and each opening introduces him under a fresh alliterative nickname: Cheshire Charles, the Svelte Snake, the hot hooligan, the lingering malingerer. Thinking up that name is, as Kat reminds him, the only thing he has to prepare. He often arrives without one. That affectionate needling sets the tone for everything after, as Kat lays out a case and Charles interrupts with questions, suspicions and early verdicts, only to be told he has to wait. The material underneath is grim. The episode titled 'Clueston 55: Back The Clue, The Murder Of Officer Elston Howard' quotes Houston police officials on robberies at adult bookstores, including a spokesman who had no explanation for why the information never reached other divisions. The conversation also stops on how taboo those stores once were, and how hard that is for a younger generation to grasp. Another case follows a man with a known history of mental illness, two hospitalizations and a rooftop rescue by firefighters, and the pair ask whether his psychiatric care should have seen the danger coming. One story concerns a young girl taken by a stranger, told in difficult detail. Another centers on Mark Castellano and Michelle: the hard drives are missing, there is a trail of bleach to the front door, and Mark put an eight-hour drive through the night down to helping his son. That episode closes by thanking Michelle's daughter for a five-star review, then ends with a recording the daughter made of her mother singing at a wedding reception. It is a small choice, and it keeps a victim from shrinking into a case file. Away from the cases, the humor is loose and self-mocking. The two joke about how long it has been since they last recorded. They also joke about the ads they switched off after political spots appeared, which left them with no income from the show. In one episode their daughter Madeline, home from medical school, sits in, renames Charles Happy Hagrid and ends up as the Mad Medic herself. The episode titles bend 'clue' into puns, such as 'Clueston 52: If The Clue Fitz.' and 'Clueston 54: One Clue Over The Cuckoo's Nest'. One episode thanks someone named Dina for recommending its case. The close follows a set pattern: the photos they took go up on the show's Instagram and its Facebook group, listeners are asked for reviews on Apple Podcasts, and a sign-off turns p's and q's into a clue pun.