Cardiovascular research, translated issue by issue.
Circulation on the Run follows each issue of Circulation through a clinician-facing lens. Co-hosts move from journal highlights into featured studies on heart failure, imaging, obesity, vaccines, myocarditis, atherosclerosis, and cardiovascular outcomes.
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Circulation on the Run is a clinician-oriented companion to Circulation, organized around the research and commentary appearing in the journal. Its recent episodes move issue by issue, usually starting with a survey of selected articles before narrowing into a featured paper. The tone is collegial and brisk. It assumes comfort with clinical vocabulary. That assumption lets the conversations spend less time defining basic terms and more time on why a study was designed the way it was. The show’s center of gravity is cardiovascular evidence in motion: new comparisons, new imaging approaches, new outcome data, and the limits that still remain. A recent feature compares GLP-1 receptor agonists with DPP-4 inhibitors and SGLT2 inhibitors in type 2 diabetes, using target trial emulation to discuss heart failure hospitalization risk. Another follows physical activity, training load, coronary calcification, and subclinical coronary artery disease in middle-aged and older athletes. Cardio-oncology appears through tyrosine kinase inhibitors and pulmonary arterial hypertension. Electrophysiology and imaging meet in discussion of ventricular tachycardia ablation and post-ablation scar characteristics on late gadolinium-enhanced MR. Prevention enters through high-dose influenza vaccine and cardiovascular outcomes. Metabolic risk is handled through obesity severity, BMI categories, heart failure, atrial fibrillation, and sex differences in risk patterns. The show also covers severe clinical territory, including acute eosinophilic myocarditis, endomyocardial biopsy, mortality, and heart transplantation. Its value is not just topic selection. The useful part is the handoff between paper summary and author-editor conversation, where methods, motivation, limitations, and implications sit together. Circulation on the Run suits a listener who wants cardiovascular research filtered through clinical relevance without stripping out the scientific machinery.
Made for: Suits a listener who follows cardiovascular medicine closely and wants clinical research framed through methods, outcomes, and editorial context. Best for someone comfortable with technical discussion of trials, imaging, therapies, and disease mechanisms.
What sets it apart: The show pairs issue-level journal navigation with featured author and editor conversations, keeping both the paper’s clinical significance and its study design in view. It is more research-room briefing than broad health explainer.
Each 15-minute podcast begins with an overview of the issue's contents and main take-home messages for busy clinicians on the run. This is followed by a deep dive into a featured article of particular clinical significance: views will be heard from both author and editor teams for a "behind the scenes" look at the publication. Expect a fun, highly conversational and clinically-focused session each week!
The cardiology mailbag leads to the study authors, where your follow-up questions get airtime.
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Short reviews from the PlayNext desk, based on the episodes we processed.
A clear, clinically grounded comparison of diabetes drugs through the lens of heart failure risk.
Circulation on the Run's April 14 issue centers on a practical cardiovascular question: how GLP-1 receptor agonists compare with DPP-4 and SGLT-2 inhibitors for patients with type 2 diabetes when heart failure hospitalization is the outcome. Dr. Petter Meyre and Dr.
Endurance training duration and its possible link to subclinical coronary artery disease.
This PlayNext episode starts with the familiar cardiovascular upside of endurance exercise, then narrows into the harder question of training load: how duration and intensity may relate to coronary arterial calcification and stenosis. Dr. Greg Hundley and Dr.
A method-minded review of rare treatment risk, myocardial scarring, and the limits that shape cardiovascular evidence.
Cardio-oncology anchors this PlayNext review as Circulation on the Run looks at how tyrosine kinase inhibitors used in many patients can, in some situations, be associated with pulmonary arterial hypertension.
A measured look at how MRI may track scar substrate and conducting channels after VT ablation.
This Circulation on the Run episode gives ventricular tachycardia ablation a measured, imaging-focused read, pairing electrophysiology with cardiovascular magnetic resonance to ask how MRI might help identify ablation sites and track scar substrate over time.
Circulation on the Run reviews Danish pooled trial evidence on high-dose versus standard-dose influenza vaccination.
Circulation on the Run's March 17 issue turns to a high-dose influenza vaccine and its possible cardiovascular stakes. Greg Hundley and Petter Meyre set up a feature paper from Denmark, a pre-specified pooled analysis of almost 500,000 people comparing high-dose and…
A clear look at severe obesity, cardiovascular risk, and the biology still left to explain.
This single-episode review centers on a cohort study of obesity severity and nine cardiovascular outcomes, asking what a very high body mass index still predicts after traditional risk factors are taken into account. Dr.
Oncology evidence translated into clinical decisions.
Critical care evidence, carefully talked through.
Clinical research, reduced to its practical signal.
Circulation on the Run’s April 14, 2026 issue covers DAPK2 and PKM2 in oscillatory shear stress, a 6,120-patient hypertrophic cardiomyopathy registry, and LVAD recovery biology before the feature interview.
Circulation on the Run for April 7, 2026 centers on a feature paper linking objectively measured training load with coronary atherosclerosis in middle-aged and older athletes.
Circulation on the Run’s March 31, 2026 issue opens with Greg Hundley and Petter Meyere discussing a Mayo Clinic study of 325 patients that found about one in five adjudicated group one pulmonary arterial hypertension cases had resting wedge pressures above 15 mmHg.
Circulation on the Run on March 24, 2026 opens with Dr.
Circulation on the Run for March 17, 2026 opens with a pooled analysis of two influenza vaccine RCTs that included just over 466,000 participants from Denmark and Spain.
Circulation on the Run’s March 10, 2026 issue examines cardiac metabolism, pediatric parvovirus B19 myocarditis, immune checkpoint inhibitor complications, and obesity severity.
Circulation on the Run's March 3, 2026 issue examines acute eosinophilic myocarditis alongside studies of athletic bradycardia, doxorubicin cardiotoxicity, and LVAD-related heart recovery.
Circulation on the Run's February 24, 2026 issue reviews systemic embolic events in 71,683 atrial-fibrillation patients, where standard-dose NOACs reduced events by 29% versus warfarin and 30-day mortality was 18%.
Circulation on the Run’s February 17, 2026 issue features Amelia Benjamin discussing career setbacks, mentorship, coaching, and depression with Jane Farr, Sana Al-Khatib, and Mercy Carnethon.
Circulation on the Run's February 10, 2026 issue examines stressor-associated atrial fibrillation through the VITAL-AF trial, which followed 30,000 primary-care patients aged 65 and older.
This episode discusses a preclinical mRNA therapy for arrhythmogenic right ventricular cardiomyopathy and a clinical study on revascularization strategies in STEMI vs NSTEMI patients.
This episode discusses the importance of lipoprotein(a) in Asian vs European populations and explores the role of splenic extramedullary hematopoiesis in cardiac repair after myocardial infarction.
This episode discusses a study on adding GLP-1 agonists to SGLT2 inhibitors in type 2 diabetes and explores the role of the cardiac lymphatic system in heart failure with preserved ejection fraction.
This episode discusses a sub-study from the early TAVR trial on using cardiac biomarkers to predict treatment response in asymptomatic aortic stenosis, and a preclinical study on circular RNA-derived proteins in vascular smooth muscle cells.
This episode discusses a randomized clinical trial on sending reminders to cardiologists about severe aortic stenosis and explores the link between periodontitis and atrial fibrillation.