Articles of Interest is built around long-form narrated essays in which Avery Trufelman traces a piece of clothing, a designer, or a dress code back through history to a larger argument about identity, labor, gender, or power. Some episodes are structured as interviews, such as a conversation with journalist Elizabeth Evitts Dickinson about designer Claire McCardell, or a segment in which Radiolab founder Jad Abumrad interviews Trufelman herself about her reporting process. The show also runs crossover episodes with other Radiotopia-network programs, including a Memory Palace-produced episode on designer Anne Lowe narrated by Nate DiMeo. Recurring subject matter includes the military-civilian divide (a multi-episode 'Gear' series on issued equipment, camouflage, and veteran homelessness), costume design for film, forgotten or overlooked American designers, religious dress, and the fashion history embedded in comics and other pop-culture artifacts. Sourcing draws on historians, industry insiders, and firsthand subjects, such as veterans discussing gear return policies or Erin Brockovich discussing her own costuming. The tone is research-driven and narrative rather than casual chat, with sponsor breaks that often promote sibling Radiotopia shows like The Heart and Vogue's The Run-Through. Listeners who follow the show tend to be interested in design, cultural history, and how clothing choices reflect institutions from the U.S. military to the Catholic Church to Seventh Avenue. There is no single recurring guest across every episode; guest appearances vary by topic and are usually subject-matter experts, journalists, or crossover podcast hosts. Production is narration-forward with edited interview tape woven in, consistent with other Radiotopia documentary-style shows.