Transplant papers, clinically argued.
AJT Highlights follows editors, interns, and guests through selected American Journal of Transplantation papers. The conversations move from study design and mechanisms to clinical implications, with transplant nephrology, hepatology, surgery, infectious disease, and bioethics appearing across the sampled episodes.
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AJT Highlights is a technical editorial companion to the American Journal of Transplantation, built around papers selected from recent issues. Its center of gravity is transplant medicine in practice: what a study found, how convincing the methods are, and what the findings might mean for clinicians, investigators, and policy-minded specialists. The format is direct. A host or co-host lays out the papers, then editors, interns, and guests move through the science with the cadence of a specialist journal club. The conversations are not simplified into broad wellness advice. They stay close to transplant nephrology, hepatology, surgery, immunology, infection, organ preservation, and allocation. That makes the show demanding, but also unusually useful for listeners who already know the field. Recent episodes cover invasive mold infection in heart transplant recipients, regulatory T-cell tracking, semi-direct allopresentation, kidney voucher modeling, thrombotic microangiopathy, glycocalyx protection, machine perfusion, procurement biopsy practice, borderline rejection, and donor-derived cell-free DNA. Historical episodes widen the frame, bringing organ transplantation, blood transfusion, skin grafting, bioethics, and early experimental physiology into the same intellectual territory. The show’s personality comes through in the contrast between dense science and relaxed professional exchange. Speakers acknowledge uncertainty, flag weak subgroup numbers, and sometimes admit when a statistical model is difficult to parse. That candor matters. It keeps the discussion from becoming a promotional summary of published papers. AJT Highlights is best for transplant professionals, trainees, and research-adjacent listeners who want editorial interpretation with the caveats left in. It also suits medically fluent listeners interested in how evidence moves from animal models, observational cohorts, randomized trials, and mechanistic assays toward clinical judgment. The result is compact, expert, and highly field-specific. It is less a general medical podcast than a readout from inside transplantation’s working debates.
Made for: AJT Highlights is for AJT readers, transplant professionals, researchers, and medically fluent listeners who want context on transplantation papers. It assumes familiarity with clinical research language and transplant biology.
What sets it apart: The show pairs article summaries with candid editorial discussion of mechanisms, limitations, subgroup uncertainty, and practice relevance. It keeps the specialist vocabulary intact instead of smoothing transplantation research into general medical commentary.
Host Roslyn Mannon, MD, discusses the latest issues of the American Journal of Transplantation, summarizing Editors’ Picks by highlighting the key messages, broader impact, and take-home points of each article. The views are her own and do not necessarily reflect those of the journal or the societies that support it.
A transplant paper meets Roz Manin's speed bump: how much can those small subgroups really prove?
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Short reviews from the PlayNext desk, based on the episodes we processed.
A careful tour of transplant research, from invasive mold infection to cell tracking and semi-direct allopresentation.
AJT Highlights' April 2026 Editor's Pick podcast frames the issue's selected papers as a measured tour through practical and mechanistic questions in transplant medicine.
A clear, grounded history of transplantation, from dog-kidney experiments and blood transfusion to the ideas that shaped the field.
Transplantation history comes through as a chain of experiments, operations, and ideas that slowly made the field possible. Thomas Schlick traces the problem through early kidney work, where dog kidneys could survive when moved within the same animal but failed between different…
Transplant research, surgical history, and the uncertain math behind future organ-donation vouchers.
Dr. Justin Barr brings transplant medicine into a wider historical frame, pairing his work as a hepatobiliary surgeon interested in organ donation with a PhD in history and a deep interest in the history of surgery.
A technically rich transplant-research discussion, grounded in clinical problems and mechanisms still seeking proof.
AJT's February Editor's Pick podcast shapes a specialist journal roundup into a focused conversation about what transplant research is trying to prevent, repair, and explain.
A dense editorial roundtable turns transplant papers into live questions about diagnosis, evidence, and treatment.
AJT January 2026 Editors' Picks opens with transplant medicine in working-session mode. Roz Manin is joined by Alberto Sanchez Fuego and Al Kassem for a discussion that begins with papers on kidney procurement biopsy, machine perfusion, and allograft outcomes, then steadily…
Oncology evidence translated into clinical decisions.
Critical care evidence, carefully talked through.
Clinical research, reduced to its practical signal.
["Rosalind Manin, Alberto Sanchez-Fuego, and Cesar Berto open AJT Highlights for the April 2026 issue by previewing four papers on heart-transplant mold infection, kidney-transplant regulatory T cells, mouse allopresentation, and dual co-stimulatory blockade.", "Baptiste Hollinger's 14-center French study of 120 heart-transplant cases reports a 3.1% first-year invasive mold incidence, a median onset around 120 days, and about 25% mortality.", "Alberto Sanchez-Fuego walks through CTOP21, where 18 of 27 kidney-transplant patients were randomized, no severe cell-product toxicity appeared, and deuterium tracing found infused material in effector T cells and graft Tregs.", "Zhou Shi Li's mouse study links CLK1, TMEM16F, and niclosamide to reduced donor-MHC cross-decoration, while Flavia Vincente's Dazodalibep-plus-belatacept trial reports 25% composite efficacy failure despite 100% graft and patient survival."]
["AJT Highlights host Justin Barr speaks with Thomas Schlick and Susan Lederer about the history of transplant, from 19th-century thyroid surgery to 20th-century blood and cornea work.", "Schlick argues that Theodor Kocher's goiter surgery in Bern, Switzerland, and a July 1883 thyroid-tissue transplant to a gardener mark the start of modern organ transplantation.", "Lederer follows blood transfusion, skin grafting, and cornea donation through California's 1947 eye-disposition law and the later anatomical-gift statutes of the 1950s and 1960s.", "The interview also covers race-based blood rules in the United States, Arkansas and Louisiana's transfusion laws, and xenotransplantation experiments shaped by organ scarcity."]
Vanderbilt’s PA-led heart procurement model covered 130 of 497 adult recoveries, showed no difference in graft outcomes, and cut physician procurement time by about 46.7 hours per quarter.
AJT Highlights' February 2026 Editors' Picks opens with Rosalind Mannen, Alberto Sanchez-Fueyo, and Juan Pablo Wiedebro previewing five transplant papers on TMA, erythropoietin, ischemia-reperfusion injury, PTLD, and bloodstream infection.
AJT January 2026 Editors' Picks opens with a kidney procurement biopsy study from 14,000 adult deceased-donor transplants in the OPTN database, and even the poorer biopsy/perfusion groups still had about 5.9 years of death-censored mean graft survival.
Roz Manin opens the December 2025 AJT Editors' Picks with five papers spanning liver hemodynamics, kidney rejection biomarkers, lung tolerance biology, patient-reported immunosuppression burden, and CMV prophylaxis.
Teresa Pou-Yu Chang's NYU Langone study says the OPTN kidney biopsy policy pushed required-biopsy adherence from 91% to 96% without worsening kidney non-use.
AJT Highlights' October 2025 Editors' Picks covers five kidney-transplant papers spanning hypothermic machine perfusion, donor mesenchymal stromal cells, UPAR/FPR signaling, DCD death determination, and CTOT19 natural antibodies.
AJT Highlights for September 2025 opens with a liver-transplant cardiology paper on blunted cardiac reserve from the University of Melbourne and Victorian liver transplant group.
AJT Podcast's discussion of kidney transplantation for undocumented immigrants in the United States centers on insurance barriers, state policy, and transplant ethics.
Experts discuss the impact of the 2018 heart allocation policy change and lessons from lung transplant's continuous distribution system.
Editors from the American Journal of Transplantation discuss five selected papers from the May 2023 issue, covering genetic evaluation of living kidney donors, EBV mutations in pediatric transplant, kidney DRI updates, and the term 'discard'.
Hosts introduce four articles from the April 2023 edition of AJT, covering liver transplant for undocumented immigrants, vitamin K in kidney transplant recipients, ABO genotyping for kidney transplants, and a cardiac paper on oxidative stress.
Roz Manin and Allie Strauss discuss editor's picks from the March 2023 issue of AJT, covering xenotransplantation, disparities in transplantation, and other transplant-related research.
Editors discuss five selected papers from the American Journal of Transplantation, covering BK virus in lung transplants, pre-transplant cancer mortality, kidney waiting times, declined organs, and DCD procurement best practices.