The Disappearing Spoon: a science history podcast with Sam Kean · Sam Kean, Bleav

The Woman Who “Turned Back a Plague of Old Testament Proportions”

November 12, 2024·19 min·1 clip
Thalidomide caused birth defects in 100,000 European babies, and Frances Kelsey was the only person who could stop it in the US.
This episode tells the story of Frances Oldham Kelsey, the FDA pharmacologist who in 1960 single-handedly blocked the approval of the dangerous drug thalidomide in the United States, preventing a birth-defect disaster that affected 100,000 babies in Europe. It explores her personal history, the intense pressure she faced from pharmaceutical company Merrill, and how her stand transformed FDA drug approval processes forever, creating both lifesaving safeguards and bureaucratic delays.

As heard by us

A bureaucratic refusal turns into a small, sturdy act of courage.

The episode uses Frances Oldham Kelsey's fading fame to tell a crisp story about a quiet FDA reviewer who pushed back on thalidomide. It keeps the facts moving: Kelsey was once honored by President John F.

Read the full review in PlayNext →

Why you'd press play

Hear how Frances Oldham Kelsey at the FDA refused to rubber-stamp thalidomide.

Read the full recommendation in PlayNext →
Listen to the show on