The Curbsiders Internal Medicine Podcast · The Curbsiders Internal Medicine Podcast

#515 Primary Aldosteronism, A Deep Dive with Anand Vaidya, MD

·1 hr 26 min·5 clips

Aldosterone was 11 ng/dL, plasma renin activity 0.5, and the ARR was 22 with normal potassium.

1. The Curbsiders Internal Medicine Podcast episode #515 covers primary aldosteronism and practical management of hyperaldosteronism. 2. Matthew Frank Watto hosts with Paul Nelson-Williams and co-host/producer Dr. Mabeen Ahmad, who frames the discussion as hypertension teaching. 3. Dr. Anand Vaidya matters here because he leads the Division of Endocrinology, Diabetes, and Metabolism at Mass General Brigham and Women’s Hospital and directs the Center for Adrenal Disorders. 4. The episode is for clinicians who want a practical approach to diagnosing and treating primary hyperaldosteronism. 5. Watto says Vaidya offered “new stuff” and a different approach from other experts the hosts had previously interviewed. 6. The hosts present the show as an Internal Medicine podcast that uses expert interviews for “clinical pearls and practice-changing knowledge.” 7. A clinical vignette centers on a 45-year-old man with hypertension, hyperlipidemia, and obesity at an annual checkup. 8. The vignette records blood pressure at 145 over 92 millimeters mercury and notes that the patient says his readings are usually elevated at home. 9. The transcript also says he was started on potassium supplements years earlier after low potassium was found. 10. Screening data are given with aldosterone 11 nanograms per deciliter by LC-MS, plasma renin activity 0.5 nanograms per milliliter per hour, and an aldosterone-renin ratio of 22. 11. The same case notes a normal potassium level at the time of screening. 12. Vaidya’s professional background includes taking care of patients with complex adrenal disorders. 13. The hosts also say he leads an NIH-funded translational laboratory. 14. That lab studies human physiology, mechanistic clinical trials, and population-based studies. 15. The episode repeatedly returns to the idea that primary aldosteronism should be handled with a structured clinical workflow. 16. Ahmad says he is ready to talk about hypertension and “kind of change the world with this aldosterone talk.” 17. The style is an interview with host banter, a brief comedic aside, and a case-based setup before the teaching begins. 18. The tone stays conversational and clinically focused, with the hosts signaling that the goal is practical bedside use. 19. Best for internists, primary care clinicians, and endocrine learners managing hypertension. 20. Skip it if you want general medicine talk without endocrine detail.

Listen to the show on

Apple Podcasts Spotify

Play clips from this episode More from The Curbsiders Internal Medicine Podcast