Sausage of Science · Human Biology Association

SoS 225: Dr. Tom Brutsaert dive deep into the role of the spleen during intense physical activity

·42 min·4 clips

Dr. Tom Brutsaert reveals how gene-environment interactions shape athletic ability and health in Andean populations.

Dr. Tom Brutsaert is a professor and researcher specializing in human adaptation, particularly to high altitude. He joins hosts Liz and Ryan, both alumni of his former institution, the University at Albany SUNY. Ryan specifically studied under Dr. Brutsaert as a former professor. The conversation centers on Brutsaert's field research with indigenous Andean populations, including the Quechua of Peru and the Aymara of Bolivia. His work investigates the genetic and physiological basis for traits adapted to high-altitude environments. A key focus is on variations in gas exchange and the control of breathing among these native groups. Brutsaert employs genome-wide association studies to identify genetic markers linked to these adaptive traits. His research program also includes a laboratory-based component examining developmental origins of health and disease. This DOHaD approach studies how early life, intrauterine development influences adult exercise capacity and disease risk. Projects in this area have involved studying U.S. college students to track these long-term effects. The discussion details the specific challenges of conducting physiological fieldwork in remote, high-altitude locations. Brutsaert explains the comparative frameworks used to study different high-altitude native populations globally. One surprising insight is that Andean and Tibetan populations have evolved different genetic solutions to the same hypoxic stress. The episode reveals how modern genomic tools are clarifying decades-old anthropological questions about human adaptation. Brutsaert describes the practical logistics of transporting and operating sensitive laboratory equipment in the Andes. A memorable moment involves the discussion of how developmental plasticity interacts with genetic adaptation over a lifetime. The research suggests early life exposures can permanently alter adult physiology and performance. Brutsaert provides specific examples of measurable traits, like resting ventilation rates, that differ in adapted populations. The tone is educational and conversational, reflecting a reunion between a former student and professor. The style is interview-based, with the hosts asking detailed, informed questions about the research methodology. Listeners hear a clear, expert breakdown of complex biocultural anthropology and physiology topics. This episode would appeal to students and enthusiasts of human evolution, sports science, and anthropological genetics. Listeners seeking a casual, narrative-driven story or broad philosophical discussion might find the detailed scientific focus less engaging.

Listen to the show on

Apple Podcasts Spotify

Play clips from this episode More from Sausage of Science