Ep. 439 Lizzy Weisman - The Miracle of Ozempic

·1 hr 28 min·5 clips

Lizzy Weisman discovers her boyfriend's 'dick cream' on the counter and confronts him about it.

The episode opens with host Randy Valerio welcoming back comedian Lizzy Weisman after about a year. Lizzy immediately notes she's thinner, leading to a discussion about Ozempic and similar GLP-1 drugs. She reveals she's on Zepbound, an FDA-approved weight-loss medication. Lizzy shares an anecdote about finding her boyfriend's 'dick cream' for erectile dysfunction on the counter. The conversation shifts to marriage, with Lizzy discussing potential engagement plans and a trip to Mexico. She talks about freezing her eggs and introduces her dog, Mitzi. Lizzy recounts her Jewish mother's blunt comment that she should have been pre-diabetic to get insurance coverage for the medication. This leads to a broader discussion about Jewish cultural stereotypes, including paying for better seats in temple. Lizzy reveals she tried her sister's breast milk and that her boyfriend tried a breast pump out of curiosity. They discuss extended breastfeeding, children in strollers at older ages, and comedian Mayim Bialik. The talk turns political, covering Trump, the Israel-Hamas conflict, and apathy. Lizzy mentions plans to possibly move to Panama. They discuss airport line-cutters, with Lizzy sharing a story of confronting a cutter in Thailand. The conversation covers TSA Clear, Southwest Airlines seating changes, self-driving cars, and ketamine use at a wedding. Lizzy describes her recent drug experimentation phase with her boyfriend, involving cocaine and molly. They note a generational decline in alcohol consumption. Lizzy details her Zepbound regimen, including cost ($500/month with a coupon), side effects like nausea, and increased hunger when off it. They critique pharmaceutical pricing and the old food pyramid. The discussion moves to AI, with Randy using ChatGPT for work reviews but noting its censorship, especially around sexual topics. They speculate about AI taking jobs, but note trades like barbering and plumbing may remain safe. Lizzy talks about her comedy style, preferring setup-punch jokes over crowd work or pure storytelling. Randy shares a joke about restaurant forks. They discuss a study finding 45% of Gen Z men have never asked a woman out in person, linking it to eroded social skills post-COVID. Lizzy describes coaching a teenage boy on how to talk to a girl. The episode ends with news about Instagram testing a dislike button and nostalgic fashion trends like frosted tips.

As heard by us

A candid Ozempic conversation lands best when medical detail crashes into body image, boner pills, and casual oversharing.

Ozempic gives Ready Set Blow a loose comic setup, then a returning guest turns it into a frank, funny pass through secrecy, body image, and the awkward social code around GLP-1 drugs.

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Why you'd press play

You get Ozempic talk, boner-pill confusion, and a Demi Moore detour in one gloriously loose catch-up.

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