Neuroscience and Beyond · Neuroscience and Beyond

Neuroinflammation & Alzheimer’s Disease | Prof. Michael Heneka on Immune Signaling and Neurodegeneration

·42 min·1 clip

If we address obesity, hearing loss, hypertension, and other factors, we could cut Alzheimer's patient numbers in half.

Professor Michael Haneke, Director of the Luxembourg Center for Systems Biomedicine, discusses the mechanisms and prevention of Alzheimer's disease through neuroinflammation research. The conversation covers the three pathological hallmarks of Alzheimer's (amyloid-beta, tau, neuroinflammation), early detection biomarkers, and the Lancet Commission's finding that addressing 14 modifiable risk factors could reduce Alzheimer's cases by 47%. Haneke highlights the complexity of personalized medicine in neurodegenerative disease compared to oncology, discusses genetic risk factors like APOE4, and explores emerging connections between viral infections and neuroinflammation.

As heard by us

A clear look at how protective brain immunity can become part of the damage.

The episode treats Alzheimer’s as the result of several pressures acting together: genetic background, risk variants, lifestyle, environment, and the ways they overlap.

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Why you'd press play

If you want Alzheimer's explained through the brain's immune system and the gene-environment puzzle behind it.

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