Mastering Nutrition · Chris Masterjohn, PhD

Can B12 and Folate Help Detoxify Oxalate?

·16 min·1 clip
Why does high-dose biotin cause oxalate crystals to exude from skin and eyes in some people but not others?
Chris Masterjohn explores whether vitamin B12 and folate can help detoxify oxalate, explaining how high-dose biotin may cause oxalate dumping symptoms in some individuals. He presents a two-step biochemical model for oxalate detoxification and discusses nutrient requirements, genetic factors, and practical testing strategies to optimize metabolic health.

As heard by us

A dense biochemical walk-through of oxalate claims that rewards listeners who want mechanism, not slogans.

The episode starts with a practical question: why biotin may trigger oxalate-dumping symptoms in some people while seeming to help others. It then works through the underlying machinery, moving through folate, B12, methylation, purine synthesis, and the pentose phosphate pathway…

Read the full review in PlayNext →

Why you'd press play

You want the chemistry behind oxalate symptoms and the B12-folate angle.

Read the full recommendation in PlayNext →
Listen to the show on